Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/3734
Title: Papaya-Derived Carbon-Dot-Loaded Fluorescent Hydrogel for NIR-Stimulated Photochemotherapy and Antibacterial Activity
Authors: Panda, Snigdharani
Pattnayak, Bibek Chaw
Dash, Priyanka
Nayak, Bismita
Mohapatra, Sasmita
Keywords: hydrogel
photodynamic
eactive oxygen species (ROS)
nanodrug
Issue Date: Aug-2022
Citation: 161st Birth Anniversary Acharya P. C. Ray & International Seminar on Recent Advances in Chemistry and Material Science (RACMS – 2022)
Abstract: The improper use of antibiotics results in the emergence of drugresistant microbes which is a serious concern to public health. Here, an NIRstimulated fluorescent antibacterial gel has been formulated by encapsulating papaya leaf-derived carbon dots (PCQDs) in a thermosensitive PVA-melamine hydrogel. This antibacterial gel can release anticancer drug 5-Fu in a spatiotemporal and dosage-controlled manner under the exposure of a 980 nm NIR laser. PCQDs can precisely generate the photothermal effect and reactive oxygen species (ROS) under NIR which induce a significant antibacterial activity in both Gram-positive and Gram-negative bacteria in a controlled manner. At the same time, a customized delivery of 5-Fu minimizes the side effect of the drug. Consequently, this innovatively designed fluorescent gel exhibited an antimicrobial effect and can act as a promising material for the NIR-responsive release of anticancer drug 5-Fu as demonstrated in B16F10 melanoma cells
Description: Copyright belongs to proceeding publisher
URI: http://hdl.handle.net/2080/3734
Appears in Collections:Conference Papers

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