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INTRODUCTION: Medicinal plants have their own biological activity and act as a better reducing and capping agent for metal ions to turn into respective metal nanoparticles. Metal NPs synthesized by biological means show better antimicrobial propensity and anti-cancerous activity than their chemical counterparts. However, the exact reason behind this is still obscure, and the need of the time. AIM AND OBJECTIVE: To unveil the bioactive components of corona responsible for the enhanced antimicr...
In this work, the hydrodynamic behaviour of a three phase annular fluidized bed with low-density integrated photocatalytic adsorbent (IPCA) particles is characterized and correlations are developed based on dimensional analysis. This is done to enable successful design and operation of a three phase annular fluidized bed (TPAFB) photocatalytic reactor that is a promising device for photocatalytic degradation of pollutants from wastewater. The solid particles used are TiO2 supported integrated...
Low-dimensional organic-inorganic metal halides (OIMHs) have garnered immense attention and extensive research in the field of solid-state lighting materials owing to their outstanding self-trapped exciton (STE)-induced luminescence properties. [1] Though there has been significant research activity in the field of lead-based hybrid metal halides, these compounds suffer from environmental toxicity and atmospheric instability. [2,3] Thus, it is significant to explore new and promising material...
Introduction: Parkinson's disease (PD) is a multifaceted progressive neurodegenerative disorder, often characterized by the loss of dopaminergic neurons and the abnormal accumulation of amyloid plaques with alpha-synuclein (αS) as major constituents. αS is an intrinsically disordered protein of 140 amino acids with the potential to form several cytotoxic fibrillation intermediates. Small molecules (especially phytochemicals) with anti-amyloidogenic potential have been reported to tackle PD on...
Gliomas are classified as one of the most lethal cancers owing to their invasive and aggressive nature. Numerous genetic and epigenetic changes have been studied in the development and progression of GBM. Dysregulation of epigenetic function may bring about profound changes in gene expression to facilitate glioma formation and development. SETD2, a key epigenetic regulator is frequently mutated in various cancers; SETD2 regulates m6A mRNA methylation (epitranscriptome) via H3K36 trimethylatio...
This study aims to develop a novel bioactive hydrogel designed to enhance wound healing through the synergistic combination of modified hyaluronic acid (HA), chitosan, and natural bioactive agents such as curcumin, aloe vera, and green tea extracts. The bioactive hydrogel was synthesized utilizing a combination of hyaluronic acid (HA) and chitosan as the foundational structural components. To enhance the therapeutic potential, natural bioactive agents—curcumin (for anti-inflammatory and antio...
This work mainly focuses on the study of the vibro-thermography effect using the concept of LDR on the circular-shaped FBH and low velocity impact (i.e., < 10 m/s) created on CFRP plates of dimensions (a) 130*65*3 mm and (b) 100*100*3.5 mm using an end milling tool and a low velocity portable impactor, respectively. The composite sample is fabricated using the VARTM method. To find out the LDR frequency of FBH and surface crack, the sample is vibrated by providing wide band sweep excitation t...
Piezoelectric ceramics are widely used as actuator, resonator, spark igniter and energy harvesting applications. Lead-free (Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 (BCZT) piezoelectric have garnered immense interest due to their excellent dielectric and piezoelectric properties. However, the conventional sintering process for BCZT requires a high temperature of ~ 1500oC, which results in significant energy consumption. Recently, the cold sintering process (CSP) has emerged as a promising alternative, ena...
In this work, Ag nanoparticles decorated NiFe2O4 /CuWO4 heterostructure were synthesized using the step-wise co-precipitation method. The influence of varying Ag loading on the NiFe2O4 /CuWO4 heterostructure and its electrochemical OER performance was extensively studied in 1 M KOH electrolyte. The obtained LSV profile was analyzed to determine the overpotential, Tafel slope, and onset potential. The heterostructure with an optimal Ag loading of 5 wt% required the least overpotential (1.60 V ...
Anomalous event classification automatically identifies anomalous events using the videos in an intelligent video surveillance system. However, anomalous event classification is challenging due to inherent research challenges such as the requirement of high-end computational infrastructure, data imbalances, and data scarcity. Typically, a combination of Convolution Neural Networks (CNNs) and Long-Short-Term-Memory (LSTM) are used to model the spatiotemporal dynamics of the videos for video cl...
Insulin, a peptide hormone commonly used in the therapeutic management of diabetes mellitus, undergoes aggregation at sites of recurrent injections in diabetic patients, as well as during its industrial synthesis and transportation. These aggregates are comprised of insoluble insulin fibrils and can lead to localized inflammatory reactions, and impaired insulin uptake. Therefore, it is essential to formulate strategies aimed at inhibiting insulin aggregation for therapeutic and industrial app...
At excessive concentrations in water, Chromium (VI) is a severe problem in many parts of the world and is sometimes linked to cancer. The remediation of aqueous streams from heavy metals is of particular concern due to the unmanageable and persistency of heavy metals in the environment. Many heavy metal ions can be removed from a variety of water sources using practical approaches. In the current investigation, attempt has been made to remove Chromium (VI) from aqueous solutions using Peanut ...
Introduction: Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders. It is characterized by memory loss and cognitive decline. Extracellular amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles of tau have been ascribed for the pathogenesis of AD. Aβ40/42 polypeptides, a product of abnormal cleavage of amyloid precursor protein by β-secretases (BACE1) and γ-secretases, is known to follow nucleus-dependent aggregation kinetics, which leads to the format...
The alarming rise in temperatures in recent years has increased the energy required to maintain the thermal comfort of building occupants. Phase change materials (PCMs) can store thermal energy and reduce this energy consumption. This paper summarizes the current developments in using PCMs in building construction. We discuss the working principle, the classification of PCMs, technologies to use PCMs at a material level in construction, the current problems involving PCM usage and their possi...
Quantum state transfer plays an important role in quantum information processing. A quantum network can be modeled by a graph G where the vertices correspond to the qubits and the edges represent the interactions between them. In a quantum network, we find the dynamics of some pair states with Heisenberg XY Hamiltonian remains unaffected with the change of the total structure. Graphs with perfect state transfer can be taken as analogous components of graph associated to a broad quantum networ...
Geopolymer mortar (GPM) serves as a sustainable alternative to ordinary Portland cement mortar (OPCM) by utilizing aluminosilicate precursor materials as binders. These precursors include natural resources such as metakaolin and volcanic ash, as well as industrial by-products like fly ash (FA) and ground granulated blast furnace slag (GGBFS). Despite the absence of cement, GPM faces environmental concerns due to reliance on natural aggregates, contributing to resource depletion. To address th...
The present study investigates the bond strength capability of epoxybased adhesive used for woven type Glass Fiber Reinforced Polymer (GFRP) in a Single Lap Bonded Joint (SLBJ) configuration. Cohesive Zone Modelling (CZM), encompassing a bilinear traction-separation law, is utilised to study the failure behaviour in the adhesive layer. Maximum Stress Criteria are opted for the damage initiation, and critical energy release rate is used for damage evolution and separation of the adhesive layer...
This study examines the rapid pyrolysis of tea waste utilizing two distinct pyrolysis techniques: traditional pyrolysis and microwave-assisted pyrolysis. The pyrolysis of tea waste was conducted using conventional pyrolysis at varying temperatures (400-600°C) and microwave-assisted pyrolysis at 450W. In microwave-assisted pyrolysis conducted using different susceptors (without susceptor, biochar, graphite, and activated carbon granules) in the ratio 1:1. In traditional pyrolysis, the highest ...
Biomolecular condensate formation within the cell is regulated via weak multivalent interactions between intrinsically disordered proteins (IDPs). Recent evidences suggest the formation of such condensates prior to pathogenic aggregates. The aggregated states of the presynaptic intrinsically disordered protein, α-Synuclein have long been associated with Parkinson’s disease. Although α-Synuclein aggregation is majorly driven by the non-amyloid β- component (NAC) domain, a 7-residue sequence kn...
Comprehending the fracture behaviour of concrete is a difficult task due to its multiscale heterogeneous structure at different length scales, extending from nanoscale to macroscale. The Calcium Silicate Hydrate (CSH) gel is the major binding phase in concrete structures, responsible for the overall mechanical and fractural strength. At atomic scale, interaction of CSH gel under different loading conditions can provide insights into the fracture process of concrete. To study load resistance c...
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