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dc.contributor.authorPanda, Snigdharani-
dc.contributor.authorPattnayak, Bibek Chaw-
dc.contributor.authorDash, Priyanka-
dc.contributor.authorNayak, Bismita-
dc.contributor.authorMohapatra, Sasmita-
dc.identifier.citation161st Birth Anniversary Acharya P. C. Ray & International Seminar on Recent Advances in Chemistry and Material Science (RACMS – 2022)en_US
dc.descriptionCopyright belongs to proceeding publisheren_US
dc.description.abstractThe improper use of antibiotics results in the emergence of drugresistant microbes which is a serious concern to public health. Here, an NIRstimulated fluorescent antibacterial gel has been formulated by encapsulating papaya leaf-derived carbon dots (PCQDs) in a thermosensitive PVA-melamine hydrogel. This antibacterial gel can release anticancer drug 5-Fu in a spatiotemporal and dosage-controlled manner under the exposure of a 980 nm NIR laser. PCQDs can precisely generate the photothermal effect and reactive oxygen species (ROS) under NIR which induce a significant antibacterial activity in both Gram-positive and Gram-negative bacteria in a controlled manner. At the same time, a customized delivery of 5-Fu minimizes the side effect of the drug. Consequently, this innovatively designed fluorescent gel exhibited an antimicrobial effect and can act as a promising material for the NIR-responsive release of anticancer drug 5-Fu as demonstrated in B16F10 melanoma cellsen_US
dc.subjecteactive oxygen species (ROS)en_US
dc.titlePapaya-Derived Carbon-Dot-Loaded Fluorescent Hydrogel for NIR-Stimulated Photochemotherapy and Antibacterial Activityen_US
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