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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1632

Title: Characterisation of Nanoparticle through SEM, FTIR & DSC
Authors: Parida, P
Behera, Ajit
Swain, S K
Mishra, S C
Keywords: Nanoparticles
Drug Delivery
Nifedipine
Spray drier technique
Issue Date: Dec-2011
Citation: National Conference on Processing and Characterization of Materials (NCPCM-2011), Department of Metallurgical & Materials Engineering, 2-3 December 2011, National Institute of Technology, Rourkela
Abstract: Nanoparticles are widely due as sustained drug delivery system. Due to their smaller size of controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. Nifedipine one of the calcium channel blocker use for the management of hypertension. Spray drier technique develops Nifedipine loaded nanoparticle. Primary superimulsion phase contains Drug (Nifedipine), Polymer (Ethylcellulose) & suitable non-aqueous Solvent (Dichloromethane) which are sprayed over secondary phase containing aqueous solvent with dispersing polymers (PVA). Formation of films on the surface of secondary phase dried, sieved & forward to spectroscopic analysis. FTIR spectrometer as an analytical tool shows the final formulation retains its chemical groups with nucleus (dihydropyridine) indicates no fluctuation at drug stability. DSC study shows the glass transition remains likely constant
Description: Copyright belongs to proceeding publisher
URI: http://hdl.handle.net/2080/1632
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