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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1546

Title: Qualitative Analysis of Controlled Release ofloxacin /HPMC Mucoadhesive Suspension
Authors: Subhashree, S
Chakraborti, C K
Mishra, S C
Naik, S
Keywords: Ofloxacin
Mucoadhesive suspension
Raman Spectroscopy XRD
Issue Date: Jun-2011
Publisher: IJDDR
Citation: International Journal of Drug Development & Research, April-June 2011, Vol. 3, Issue 2
Abstract: Mucoadhesive polymeric (HPMC) suspension of Ofloxacin was prepared and optimised with the aim of developing an oral controlled release gastro-retentive dosage form. The qualitative analysis of the formulation was performed by FTIR, Raman Spectroscopy, XRD and SEM analyses. Ultrasonication method was used for preparation of mucoadhesive Ofloxacin suspension. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried out and spectra were used for interpretation. X-ray powder diffraction (XRD) data of pure drug, polymer and the formulation were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. The dispersion of particle was observed using Scanning electron microscopy (SEM) techniques. The particle size distribution (PSD) and aspect ratio (AR) of particles in the polymeric suspension were obtained from SEM image analysis. The results from FTIR and Raman Spectroscopic analyses suggested that in formul...
Description: Copyright belongs to IJDDR
URI: http://hdl.handle.net/2080/1546
ISSN: 0975-9344
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