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http://hdl.handle.net/2080/1546
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| DC Field | Value | Language |
|---|
| contributor.author | Subhashree, S | - |
| contributor.author | Chakraborti, C K | - |
| contributor.author | Mishra, S C | - |
| contributor.author | Naik, S | - |
| date.accessioned | 2011-10-28T09:57:46Z | - |
| date.available | 2011-10-28T09:57:46Z | - |
| date.issued | 2011-06 | - |
| identifier.citation | International Journal of Drug Development & Research, April-June 2011, Vol. 3, Issue 2 | en |
| identifier.issn | 0975-9344 | - |
| identifier.uri | http://hdl.handle.net/2080/1546 | - |
| description | Copyright belongs to IJDDR | en |
| description.abstract | Mucoadhesive polymeric (HPMC) suspension of Ofloxacin was prepared and optimised with the aim of developing an oral controlled release gastro-retentive dosage form. The qualitative analysis of the formulation was performed by FTIR, Raman
Spectroscopy, XRD and SEM analyses. Ultrasonication method was used for preparation of mucoadhesive Ofloxacin suspension. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried
out and spectra were used for interpretation. X-ray powder diffraction (XRD) data of pure drug, polymer and the formulation were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. The dispersion of particle was observed using Scanning electron microscopy (SEM) techniques. The particle size distribution (PSD) and aspect ratio (AR) of particles in the polymeric suspension were
obtained from SEM image analysis. The results from FTIR and Raman Spectroscopic analyses suggested that in formulation, the carboxylic groups of Ofloxacin and hydroxyl groups of
HPMC undergo chemical interaction leading to esterification and hydrogen bonding (both intermolecular and polymeric). The XRD data suggested that the retention of crystalline nature
of Ofloxacin in the formulation would lead to increase in stability and drug loading; decrease in solubility and delayed release of the drug from polymeric suspension with better
bioavailability and penetration capacity. The SEM image analysis indicated that in the formulation maximum particles were having aspect ratio from 2 to 4 and standard deviation was very less, which provided supporting evidences for homogeneous, uniformly dispersed, stable controlled release
Ofloxacin suspension which would be pharmaceutically acceptable. | en |
| format.extent | 896485 bytes | - |
| format.mimetype | application/pdf | - |
| language.iso | en | - |
| publisher | IJDDR | en |
| subject | Ofloxacin | en |
| subject | Mucoadhesive suspension | en |
| subject | HPMC | en |
| subject | FTIR | en |
| subject | Raman Spectroscopy XRD | en |
| subject | SEM | en |
| title | Qualitative Analysis of Controlled Release ofloxacin /HPMC Mucoadhesive Suspension | en |
| type | Article | en |
| Appears in Collections: | Journal Articles
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Files in This Item:
| File |
Description |
Size | Format |
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| Final published paper----IJDDR.pdf | | 875Kb | Adobe PDF | View/Open |
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