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| Title: | Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension |
| Authors: | Sahoo, S
Chakraborti, C K
Mishra, S C |
| Keywords: | Carbopol 934
ciprofloxacin
mucoadhesive suspension |
| Issue Date: | 2011 |
| Publisher: | Society of Pharmaceutical Education & Research |
| Citation: | Society of Pharmaceutical Education & Research Vol 2 / Issue 3 / Jul-Sept 2011 |
| Abstract: | Mucoadhesive polymeric (carbopol 934) suspension of ciprofloxacin was prepared by
ultrasonication and optimized with the aim of developing an oral controlled release
gastro-retentive dosage form. The qualitative analysis of the formulation was performed
by fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder
diffraction (XRD), and scanning electron microscopy (SEM) analyses. FTIR (400 cm-1
to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were
carried out and the spectra were used for interpretation. XRD data of pure drug,
polymer and the formulation were obtained using a powder diffractometer scanned
from a Bragg’s angle (2θ) of 10° to 70°. The dispersion of the particle was observed
using SEM techniques. The particle size distribution and aspect ratio of particles in the
polymeric suspension were obtained from SEM image analysis. The results from FTIR
and Raman spectroscopic analyses suggested that, in formulation, t... |
| Description: | Copyright for this article belongs to Society of Pharmaceutical Education & Research |
| URI: | http://hdl.handle.net/2080/1537 |
| ISSN: | 2231-4040 |
| Appears in Collections: | Journal Articles
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| JAdvPharmTechRes_2011_2_3_195_85541.pdf | | 1341Kb | Adobe PDF | View/Open |
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