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http://hdl.handle.net/2080/1537
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| DC Field | Value | Language |
|---|
| contributor.author | Sahoo, S | - |
| contributor.author | Chakraborti, C K | - |
| contributor.author | Mishra, S C | - |
| date.accessioned | 2011-09-30T04:44:26Z | - |
| date.available | 2011-09-30T04:44:26Z | - |
| date.issued | 2011 | - |
| identifier.citation | Society of Pharmaceutical Education & Research Vol 2 / Issue 3 / Jul-Sept 2011 | en |
| identifier.issn | 2231-4040 | - |
| identifier.uri | http://hdl.handle.net/2080/1537 | - |
| description | Copyright for this article belongs to Society of Pharmaceutical Education & Research | en |
| description.abstract | Mucoadhesive polymeric (carbopol 934) suspension of ciprofloxacin was prepared by
ultrasonication and optimized with the aim of developing an oral controlled release
gastro-retentive dosage form. The qualitative analysis of the formulation was performed
by fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder
diffraction (XRD), and scanning electron microscopy (SEM) analyses. FTIR (400 cm-1
to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were
carried out and the spectra were used for interpretation. XRD data of pure drug,
polymer and the formulation were obtained using a powder diffractometer scanned
from a Bragg’s angle (2θ) of 10° to 70°. The dispersion of the particle was observed
using SEM techniques. The particle size distribution and aspect ratio of particles in the
polymeric suspension were obtained from SEM image analysis. The results from FTIR
and Raman spectroscopic analyses suggested that, in formulation, the carboxylic groups
of ciprofloxacin and hydroxyl groups of C934 undergo a chemical interaction leading
to esterification and hydrogen bonding. The XRD data suggested that the retention of
crystalline nature of ciprofloxacin in the formulation would lead to increase in stability
and drug loading; decrease in solubility; and delay in release of the drug from polymeric
suspension with better bioavailability and penetration capacity. The SEM image analysis
indicated that, in the formulation maximum particles were having aspect ratio from 2
to 4 and standard deviation was very less which provided supporting evidences for
homogeneous, uniformly dispersed, stable controlled release ciprofloxacin suspension
which would be pharmaceutically acceptable. | en |
| format.extent | 1373409 bytes | - |
| format.mimetype | application/pdf | - |
| language.iso | en | - |
| publisher | Society of Pharmaceutical Education & Research | en |
| subject | Carbopol 934 | en |
| subject | ciprofloxacin | en |
| subject | mucoadhesive suspension | en |
| title | Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension | en |
| type | Article | en |
| Appears in Collections: | Journal Articles
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| File |
Description |
Size | Format |
|---|
| JAdvPharmTechRes_2011_2_3_195_85541.pdf | | 1341Kb | Adobe PDF | View/Open |
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