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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1537

Title: Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Keywords: Carbopol 934
ciprofloxacin
mucoadhesive suspension
Issue Date: 2011
Publisher: Society of Pharmaceutical Education & Research
Citation: Society of Pharmaceutical Education & Research Vol 2 / Issue 3 / Jul-Sept 2011
Abstract: Mucoadhesive polymeric (carbopol 934) suspension of ciprofloxacin was prepared by ultrasonication and optimized with the aim of developing an oral controlled release gastro-retentive dosage form. The qualitative analysis of the formulation was performed by fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) analyses. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried out and the spectra were used for interpretation. XRD data of pure drug, polymer and the formulation were obtained using a powder diffractometer scanned from a Bragg’s angle (2θ) of 10° to 70°. The dispersion of the particle was observed using SEM techniques. The particle size distribution and aspect ratio of particles in the polymeric suspension were obtained from SEM image analysis. The results from FTIR and Raman spectroscopic analyses suggested that, in formulation, t...
Description: Copyright for this article belongs to Society of Pharmaceutical Education & Research
URI: http://hdl.handle.net/2080/1537
ISSN: 2231-4040
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