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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1442

Title: Raman Spectroscopy as an Analytical Tool for Characterization of Fluoroquinolones
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Nanda, U N
Naik, S
Keywords: Norfloxacin,
Ciprofloxacin,
Ofloxacin,
Raman spectroscopy
Issue Date: 2011
Publisher: Journal of Pharmacy Research and Association of Pharmaceutical Innovators
Citation: Journal of Pharmacy Research, Vol.4,Issue 4, Pages 1129-1131,April 2011
Abstract: The aim of this paper is to produce the basis for the Raman spectroscopy as a promising new official method for identification of fluoroquinolone antibacterials. Raman spectroscopic analysis data for three pure fluoroquinolone antibacterials like Norfloxacin, Ciprofloxacin and Ofloxacin, have been performed by a low resolution portable Raman Spectrometer (Raman system R-3000) using 785 nm solid state diode laser and having fibre optic sampling probe. The Raman spectra are collected over the wave number range from 140 to 2500 cm-1 at room temperature. From our overall Raman spectroscopic analysis, it has been found that those fluoroquinolones show prominent characteristic peaks for pyridone nucleus, piperazinyl ring, carboxylic acid and fluorine substituent. In addition, the characteristic peaks at 872.7, 771.47 and 797.5 cm -1 for Norfloxacin, Ciprofloxacin and Ofloxacin, respectively, are assigned to fully symmetric vibrational normal mode of the molecule containing the C-F bond. Sin...
URI: http://hdl.handle.net/2080/1442
ISSN: 0974-6943
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