Comparative Analysis of Feature Representation in DNA Sequence Similarity Using Alignment-Free Approaches See

Numerous methodologies have been proposed for DNA sequence similarity analysis, both Alignment-based and Alignment-free analysis. Though Alignment based methods give accurate results, in the last few decades, AF methods have proven to come close to being as effective as AB methods while overcoming a lot of limitations. Our research revealed which methods provide greater performance independently and which ones with different combination of possible methods. The feature representation has to b...

A Retinex-Inspired Approach for Enhancing Low-Light Images Captured from UAV See

Image enhancement involves enhancing an image’s quality and visibility through different techniques like contrast adjustment, noise reduction, super-resolution, and sharpening. In unmanned aerial vehicles (UAVs), image enhancement becomes crucial due to image acquisition in challenging conditions such as low-light, haze, and fog. Specifically, while addressing low-light scenarios, the goal is to enhance the visibility and finer details of images captured in dim environments. Traditional metho...

All-atom Simulations of the Phase Behavior of P1 Domain of α-Synuclein See

Biomolecular condensate formation within the cell is regulated via weak multivalent interactions between intrinsically disordered proteins (IDPs). Recent evidences suggest the formation of such condensates prior to pathogenic aggregates. The aggregated states of the presynaptic intrinsically disordered protein, α-Synuclein have long been associated with Parkinson’s disease. Although α-Synuclein aggregation is majorly driven by the non-amyloid β- component (NAC) domain, a 7-residue sequence kn...

Bacosine Inhibits Arecoline-Induced Inflammasome by Activating Autophagy Through The NRF2-TFEB Axis in Oral Cancer See

Numerous phytochemicals exhibit potent antioxidant activity, which is crucial in shielding cells from oxidative damage caused by reactive oxygen species (ROS). Amongst phytochemicals from various plants, recent studies have emphasized the antioxidant properties of Bacopa monnieri, a medicinal herb eminent for its cognitive-enhancing properties. The antioxidant properties of Bacopa are primarily accredited to its abundant content of bioactive compounds such as bacosides, flavonoids, and phenol...

PAX9 Reactivation Promotes Autophagy-Mediated Cellular Differentiation by Controlling Stemness Via AKT-GSK3-β Signaling in Oral Cancer Cells See

Paired box 9 (PAX9) is a member of the paired box family involved in cancer cell growth, proliferation, and differentiation. PAX9 downregulation has been established in oral cancer associated with cancer growth and progression. To investigate the role of PAX9 in stemness and differentiation, we initially separated CD44+ and CD44- from oral cancer cells by MACS and confirmed by flow cytometry and western blot analysis. We found that PAX9 decreased expression in CD44+ cells compared to CD44- ce...

Resonant Frequency of a Cylindrical Dielectric Coated Conductor-based Dielectric Resonator Antenna See

Cylindrical Dielectric Coated Conductor-based Dielectric Resonator Antenna (CDCC-DRA) is investigated here theoretically. Mixed magnetic wall model is used here for investigation. Fundamental mode is investigated. A cylindrical coordinate system is used to investigate the problem. The radial wavenumber is computed using mode matching technique, whereas the wavenumber along the height of the antenna is computed by applying a magnetic wall at the surface. Incremental search method is used to fi...

Anionic Vacancy Rich Bi-MOF Derived Ternary Biocompatible Nanocomposite For Enhanced Photocatalytic Application See

In this study, a one-step method was developed for construction of MOF derived Ag/Sr6Bi2O9- -Bi2O3 ternary photocatalyst for comprehensive water remediation applications. The synthesized ternary heterostructure exhibited a high surface area oxygen defect rich hierarchical nanostructure consisting of plasmonic Ag quantum dots (3-5 nm) embedded in ultrathinSr6Bi2O9 nanosheets that are epitaxially grafted over porous BO nanorods. The oxygen vacancies, tight heterojunction between SBO/BO and pla...

Snowflake Like Cu-BDC-NH2/Cu58S32 Nanocomposite for Photocatalytic H2 Evolution and O2 Reduction See

This work presents the synthesis of unique binary Cu-BDC-NH2/Cu58S32 (CSM) heterostructure which is synthesized via one-pot solvothermal route. The nonstoichiometric pure roxbyite (Cu58S32) phase was synthesized and evolution of distinct morphologies like nanoplate (np) and snowflake (sf) was achieved by varying the sulfur sources. To construct the heterostructure, Cu58S32 (CS) is used as host matrix as well as copper source to fabricate CuBDC-NH2 MOF (CM) nano plate over it. A substantial in...

Hub Genes in Driving Colon Cancer Progression: Plasma Membrane Lipid Raft Signaling Regulates the Hub Genes by Epigenetic Modulation See

Colon adenocarcinoma (COAD) ranks among the most prevalent malignant tumors, yet there remains a significant lack of comprehensive epigenetic data concerning this condition. This study uses various intelligent computational algorithm-based high-throughput data analysis tools to initially identify crucial hub genes through comparative analysis of gene-expression datasets, including GSE44076, GSE20916, and GSE37364. This study presents a novel streamlined approach for systematically screening a...

Exploring GB1 Dimerization Pathway Markov State Models See

Markov state model (MSM) is a suitable method of studying the intermediate states and pathways during the binding/dimerization process of proteins. The dimerization structure of GB1 can have two distinct shapes; domain swapped (DS) and side-by-side (SS) where the former is more stable as conformed by both simulation1 and experiment2 . Here we employ a 20 microsecond long molecular dynamics trajectory1 of GB1 dimerization starting from monomer states to construct a MSM. To identify the slow co...

A Reliable and Soft Error Tolerant 12T Radiation Hardened SRAM Cell for Aerospace Applications See

In today’s state-of-the-art VLSI circuits, the SRAMs covers a greater part of the chip area. As technology scales down and moves into the nanometer regime, memory storage elements like SRAM cells are mostly affected by the impact of radiation. Therefore, the rate of soft error generation is enhanced with technology scaling. In this work, a reliable soft error tolerant 12 transistor RTSC-12T SRAM cell is proposed that provides good radiation tolerant capability and is completely immune to SEU ...

Malachite Green Dye Degradation by Adsorption-Assisted Photocatalysis Employing Nano ZnO impregnated on GAC Derived from Unused Coconut Shells (nZnO/CSGAC) See

Wastewater containing malachite green (MG) dye has the potential to destroy the aquatic ecology and endanger human health. Therefore, an integrated adsorption and photocatalytic degradation technique was established to eliminate its presence in wastewater. In this study, ZnO photocatalytic nanoparticles (nZnO) supported on an adsorbent granular activated carbon (GAC) derived from waste coconut shells (nZnO/CSGAC) composite was used as an integrated photocatalytic adsorbent (IPCA). Various tec...

Land Surface Processes at Urban Scale Resolution on Thunderstorms Prediction See

The study highlights the need of land surface process at an urban resolving scale to improve the thunderstorm representation and the rainfall characterization, particularly over the cities. The eastern states, Odisha, Chhattisgarh, Jharkhand, and West Bengal, show increasing trends in thunderstorm activity. The rainfall characterisation of urban thunderstorms is sensitive to Land Use Land cover (LULC) representation which has been understood from observational and modeling studies. For ex...

Understanding the Language Environment: Looking into the Language Policy of Corporate India See

The importance of multilingualism for cognitive development cannot be overemphasised. India, with its multiple languages, has always been at the forefront of this ‘cultural and social capital’ that has sustained its identity through generations. Likewise, on the economic front, the World Bank forecasts a robust 7% growth for India for fiscal year 2024 ‘despite a challenging global environment’. India’s corporate sector has always played a pivotal role, with employees from all over the country...

Berberine-Induced Apoptosis in Glioblastoma Cell Lines: Involvement of ROS-Mediated Mitochondrial Disruption Through Epigenetic Reprogramming of Nrf2/HO-1 Signaling Dynamics See

Glioblastoma is the most severe form of malignant brain tumor with a mean survival rate of 12–15 months, attributed to its poor prognosis and scarce treatment alternatives. Also, the poor response and resistance to conventional radiotherapy and chemotherapy of GBM demand for the development of innovative and effective treatment modalities. Nature-derived compounds have grasped significant attention as a promising alternative for the development of novel anti-cancer drugs. Berberine is a natur...

Investigating the Role of Crown Ethers in Enhancing Metal Cation Solvation and Diffusion in Lithium and Sodium-Based Electrolytes See

The use of electrolyte additive in battery chemistry is emerging field of research towards the improvement of ion transport and solid-electrolyte-interface formation. The crown ethers are an important class of macrocyclic ligands which display a conspicuous selectivity to metal ions based on the host-guest interaction. Crown ethers are cyclic compounds with a cavity that can selectively bind metal cations like lithium and sodium. This ability to encapsulate specific cations helps in controlli...

Synergic Effects of Glucose and Trehalose on Hydrated Lipid Bilayer Properties See

The lipid bilayer is a crucial component of biological cell membranes, and proper hydration is essential for maintaining its normal functions within cells. It is hypothesized that saccharides such as glucose, sucrose, and trehalose offer protection to membranes, preventing cell rupture and stabilizing lipid membranes in aqueous environments.1-3 However, this protective effect is influenced by the concentration of saccharides, and the detailed molecular interactions between saccharides and lip...

Application of Cold Plasma Technology on Functional Properties of Millet Flour See

Millets, ancient grains valued for their nutrition and drought tolerance, include little millet (Panicum sumatrense), domesticated in India over 5,000 years ago. Despite its agroeconomic and nutritional potential, little millet remains underutilized due to its coarse nature and limited research. This study evaluates the impact of cold plasma, a non-thermal technology for improving food quality, on the functional properties of little millet flour. Key properties such as water absorption capaci...

Recent Advances in Metal-Based Theranostic Agents: Anticancer and Cellular Localization See

Today, metal-based drugs that are luminescent are crucial to diagnosis and therapeutics. In anticancer research, a fluorescent compound possessing low cytotoxicity, high fluorescence properties, and organelle specificity would prove useful for diagnosing physiological disorders related to that organelle. In short, it can act as a real-time tracking bioimaging agent. Similarly, fluorescent compounds with high cytotoxic properties help in evaluating the cell death mechanism more accurately. So,...