Exploring Genome Dynamics: From Computational Discovery to Clinical Application

Abstract

Our research develops integrative genomics frameworks to decode genome dynamics by analysing DNA sequence, structure, energetics, variation, and expression. Early work led to bioinformatics tools such as OncoRegulon and Pathogen-Specific DNA Drug Finder. We later demonstrated that DNA energetic properties distinguish functional genomic regions, advancing structural annotation through ChemGenome2.1. Postdoctoral studies revealed mutation- and structure-driven regulatory mechanisms in renal cell carcinoma, identifying TP53 and SMARCA4 as markers of aggressive disease and uncovering fusion-driven expression rewiring in translocation RCC. Current work integrates bulk, single-cell, and spatial transcriptomics to investigate tumor progression, immune– stromal interactions, and precision therapeutic targets in cancers of national relevance.