Oxido VIV-Unsymmetrical Salen Complexes: Synthesis, Solution Stability, Biomolecular Interactions, and Anticancer Activity

Abstract

Nowadays in the worldwide cancer is one of the leading causes of mortality and chemotherapy has been shown to be the most successful approach for treating cancer.1 Till now platinum-based drugs are mostly used for the treatment of cancer.2 However, these drugs have some side effects, like nephrotoxicity, neurotoxicity, and very poor selectivity towards tumour cells. In this regard, the vanadium complexes has drawn paramount interest for their biochemical, and pharmacological applications.3 Here in this presentation, three stable oxidovanadium(IV) [VIVOL1−3] complexes (1−3) were synthesized from unsymmetrical salen ligands (H2L1−3). The DNA/BSA binding properties were investigated using a variety of spectroscopic techniques, and the findings demonstrate that 1–3 exhibits efficient biomolecular interactions. According to the partition coefficient result, complexes are extremely hydrophobic and could easily enter the cells. Finally, the in vitro anticancer activities of 1−3 were determined with two cancerous (HT-29 and A549), and the NIH-3T3 normal cell lines. Moreover, the apoptotic cell death mechanism of 1−3 was assessed through DAPI, AO/EB, and double staining apoptosis experiments.