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DC Field | Value | Language |
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dc.contributor.author | Nath, Ankita | - |
dc.contributor.author | Avvari, Ravi Kant | - |
dc.date.accessioned | 2025-01-07T12:29:50Z | - |
dc.date.available | 2025-01-07T12:29:50Z | - |
dc.date.issued | 2024-12 | - |
dc.identifier.citation | 7th International Conference on Frontiers in Chemical Sciences (FICS), IIT Guwahati, Assam, 2-4 December 2024 | en_US |
dc.identifier.uri | http://hdl.handle.net/2080/4900 | - |
dc.description | Copyright belongs to the proceeding publisher. | en_US |
dc.description.abstract | With the current global surge in occurrence of diabetes, studies focus on procurement of natural products for diabetes management. Current medications of diabetes have adverse negative side effects for patients and to minimize these, natural bioactive compounds are investigated for their effect on diabetes management. Polyphenols are a diverse group of naturally occurring compounds found in plants which have garnered significant attention for their potential effects on blood glucose regulation. Polyphenols consist of several groups of chemical compounds such as phenolic acids – ex. tannic acid, gallic acid; flavonoids ex.- flavonols, flavonones; stilbenes and polymeric lignans. They can be extracted from different plant source and also available in plenty of amount in our daily diet. This study examines the impact of dietary polyphenols on glucose metabolism, highlighting their role in insulin sensitivity, carbohydrate digestion, glucose absorption, and the modulation of gut microbiota. Numerous studies suggest that polyphenols, mainly flavonoids and phenolic acids, can enhance insulin action and reduce postprandial glucose levels. Mechanistically, polyphenols may influence pathways related to oxidative stress, inflammation, and enzymatic activity involved in carbohydrate digestion. This study also explores mathematical simulation of starch digestion under in vivo conditions and further estimates the rate of glucose formation in MATLAB. Polyphenols such as tannic acid and gallic acid have shown inhibitory effects on the key enzymes for starch digestion i.e, α-amylase and α-glucosidase, thus modulating the starch hydrolysis and affecting the postprandial glucose levels. Using mathematical models on Rate Law kinetics and Michaelis-Menten equations for enzyme kinetics, we have performed preliminary studies on the rate kinetics of the formation of these metabolites and the inhibition of the enzymes by the polyphenols. The results of the kinetic assay are graphically represented using MATLAB simulation and interpreted which shows that polyphenols when in higher concentration act as competitive inhibitors for the amylase, glucosidases and intestinal brush border enzymes. Polyphenols also have effect on glucose transporters across the epithelial membranes thus also slowing down the glucose absorption rate, thus reducing postprandial hyperglycemic spike. Furthermore, the interaction between polyphenols and gut microbiota appears to enhance their bioavailability and efficacy. While results are promising, the variability in individual responses and the complexity of polyphenol interactions necessitate further research to establish specific dietary recommendations and therapeutic applications. Overall, polyphenols represent a promising avenue for managing blood glucose levels, particularly in the context of metabolic disorders such as type 2 diabetes. | en_US |
dc.subject | Polyphenols | en_US |
dc.subject | Diabetes management | en_US |
dc.subject | Starch digestion | en_US |
dc.subject | α-amylase | en_US |
dc.subject | α-glucosidase | en_US |
dc.title | Bioactive Polyphenols and Their Antidiabetic Potential and Inhibitory Effects on Starch Digestive Enzymes: A Novel Approach for Diabetes Management | en_US |
dc.type | Presentation | en_US |
Appears in Collections: | Conference Papers |
Files in This Item:
File | Description | Size | Format | |
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2024_FICS_ANath_Bioactive.pdf | Poster | 1.87 MB | Adobe PDF | View/Open Request a copy |
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