Near-Infrared-Induced NO-Releasing Photothermal Adhesive Hydrogel with Enhanced Antibacterial Properties

Abstract

Bacterial infection and the development of antibiotic-resistant bacteria have decreased the effectiveness of traditional antibiotic treatments for wound healing. In this work, a photothermal carbon dot (CD) with a NO-releasing moiety has been incorporated within an oxidized sodium alginate conjugated polyacrylamide (OS@PA) hydrogel to get a photothermal NO-releasing GSNOCD-OS@PA hydrogel. Under 808nm laser irradiation, the designed hydrogel showed a temperature rise and NIR-controlled NO release. Along with fibroblast proliferation, the photothermal NO therapy reduced bacterial viability without inducing toxicity against 3T3 cells.