Weak Coordination enabled Pd(II)-catalyzed regioselective C-H functionalization of indole

Abstract

Directing group assisted C-H activation is a potential strategy for selective functionalization of less-reactive C-H bonds. Due wide abundance in numerous natural products, pharmaceuticals and functional materials, selective functionalization of indole has gained increasing interest. Here, we unveiled the weakly-coordinating group directed Pd-catalyzed regioselective C4-H arylation, and C2-H thioarylation of indoles. Substrate scope and mechanistic insight of the strategies were investigated