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Title: Layer-specific mechanical responses and morphological structure of Atrioventricular Valve Leaflets
Authors: Babu, Anju R
Kramer, Katherine
Laurence, Devin
Wu, Yi
Lee, Chung-Hao
Keywords: Mitral valve (MV)
Tricuspid valve (TV)
Extracellular matrix (ECM)
Valve interstitial cells
Issue Date: Jul-2018
Citation: 8th World Congress of Biomechanics, Dublin, Ireland, 9 July,2018
Abstract: The mitral valve (MV) and tricuspid valve (TV) leaflets are composed of extracellular matrix (ECM) and valve interstitial cells organized heterogeneously to form four morphologically distinct layers [1]. The biomechanical properties of the valve leaflets are primarily determined by their ECM components—elastin, collagen, glycosaminoglycans, and proteoglycans [2]. Although the biomechanical properties of the intact MV and TV leaflets have been extensively investigated, little information exists on the mechanical properties of the individual leaflet layers. Hence, we aim to elucidate the relation between the mechanical response and structural properties of individual layers of the atrioventricular leaflets.
Description: Copyright of this document belongs to proceedings publisher.
Appears in Collections:Conference Papers

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