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Title: Polyether Ether Ketone Reinforced Chitosan-Polyethylene Glycol Composites for Biomedical Application
Authors: Mukherjee, Payal
Kaur, Tejinder
Namasivaya, Naveen S
Arunachalam, Thirugnanam
Keywords: Chitosan
Polyethylene glycol
Polyether ether ketone
Biomedical applications
Issue Date: Oct-2017
Citation: 6th Asian Biomaterials Congress (ABMC6), Thiruvananthapuram, Kerala, India, 25-27 October 2017
Abstract: Chitosan (CS), a naturally occurring polysaccharide, is widely being used for medical and pharmaceutical applications owing to its biocompatibility and biodegradability. However, its brittle nature and weak mechanical properties often limit its application in the biomedical field. Therefore, the aim of the present study is to reduce the brittle nature of the CS films by addition of polyethylene glycol (PEG) and to further improve their mechanical properties by reinforcing with the polyether ether ketone (PEEK). Briefly, CS (2% w/v) was dissolved in 2% acetic acid solution and stirred overnight at 37˚C. PEG in the concentration of 1% w/v was added to the CS solution and stirred again for 6 h. In the CS-PEG composite, PEEK was added at concentrations of 0.1% and 0.5% w/w (w.r.t. CS) to develop CS-PEG-PEEK composites. Thus developed three different composites were named as CP (CS-PEG), CP 0.1 (CS-PEG-0.1% PEEK) and CP 0.5 (CS-PEG-0.5% PEEK). The composites were characterized by performing scanning electron microscopy (SEM), X-ray diffraction and Fourier transform infrared study. The contact angle measurement, swelling studies, degradation studies, hemocompatibility and protein adsorption studies were also performed. The mechanical properties of the composites were evaluated by performing tensile studies. The SEM micrographs showed well dispersion of PEG and PEEK in the CS matrix. The CP showed lowest contact angle values, whereas, the addition of PEEK increased the contact angle values of the composites. The PEEK containing samples (CP 0.1 and CP 0.5) showed less swelling percentage and degradation rate than the control (CP). All the samples exhibited <5% hemolysis values confirming their hemocompatible nature. The adsorption of protein on all the composites indicated their suitability for biomedical applications. Further, the reinforcement of PEEK in CS-PEG matrix improved the mechanical properties of the composites many folds. The above studies confirm the potential of CS-PEG-PEEK composites for biomedical implant applications.
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