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Title: FTIR and Raman Spectroscopic Investigations of a Norfloxacin/Carbopol934 Polymeric Suspension
Authors: Sahoo, S
Chakraborti, C K
Behera, P K
Mishra, S C
Keywords: C934
mucoadhesive formulation
Raman spectroscopy
Issue Date: Sep-2012
Publisher: InPharm Association
Citation: Journal of Young Pharmacists, Vol 4, Issue 3, Jul-Sep, 2012
Abstract: Till now very few formulations are available from which the drug is uniformly absorbed, so that the safe and effective blood level of norfloxacin could be maintained for a prolonged period. To fulfill this requirement, a controlled release mucoadhesive suspension was prepared by using a mucoadhesive carbopol934 polymer. The chemical interaction between norfloxacin and the polymer in formulation (prepared by an ultrasonication method) has been studied by FTIR and Raman spectroscopy. From the spectral interpretation, it has been found that in formulation, the carboxylic groups of norfloxacin and hydroxyl groups of carbopol934 undergo chemical interaction, leading to esterification and hydrogen bonding. The formation of micellies due to esterification and hydrogen bonding causes more drug entrapment and a stable formulation. From this it can be concluded that the formulation of norfloxacin may give a better controlled release and mucoadhesive action in the gastrointestinal tract. Hence, carbopol934 could be considered as an effective carrier for norfloxacin.
Description: Copyright for this paper belongs to InPharm Association
ISSN: 0975-1483
Appears in Collections:Journal Articles

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