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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1708

Title: Synthesis, Crosslinking and Evaluation of Graft Polymer for Biomedical Use
Authors: Parida, P
Mishra, S C
Keywords: Graft polymer
acrylic acid
HPMC
FTIR
DSC
Issue Date: Apr-2012
Publisher: STM Journals
Citation: Research & Reviews: Journal of Pharmaceutical Science, Volume 3, Issue 1, April 2012, 37-45
Abstract: The objective of this research was focused on grafting of acrylic acid (AA) with hydroxypropyl methylcellulose (HPMC) to obtain copolymers of hydrogels with improved properties for ease of administration and reducing the dose frequency, improved patient compliance and comfort of sustained release medication. Water-absorbing polymers for hydrogels, the swellable polymeric materials have been widely investigated as the carrier for drug delivery system. These are the advanced polymer systems that hold special advantages for delivery of biological drugs and enhancing the biocompatibility of implantable devices. Here polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled release dosage forms. Hydrogel was prepared by in situ emulsifier-free emulsion polymerization using benzyl peroxide as an initiator through primary stage grafting. Acrylic acid could intercalate into layers of HPMC forms graft polymer composite. FTIR spectroscopy helps in determinin...
Description: Copyright for this paper belongs to STM Journals
URI: http://hdl.handle.net/2080/1708
ISSN: 2229–7006
Appears in Collections:Journal Articles

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