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Title: Preparation and characterisation of graft Biopolymer to improve sustained Release property
Authors: Parida, P
Dash, D
Behera, Ajit
Mishra, S C
Keywords: Ciprofloxacin
Acrylic acid
Issue Date: Dec-2011
Citation: National Conference on Processing and Characterization of Materials (NCPCM-2011), Department of Metallurgical & Materials Engineering, 2-3 December 2011, National Institute of Technology, Rourkela
Abstract: In the present piece of research work focuses on grafting Acrylic acid with HPMC to obtain copolymers with improved properties, biodegradable and biocompatible that will be used as hydrogel or water absorbing polymers. To develop a prolong release activity drug delivery system for the medication purpose to enhance drug activity and reduce the frequency of dose via this hydrogel. A novel HPMC-g- acrylic acid hydrogel was prepared by in-situ emulsifier free emulsion polymerization using benzyl peroxide as an initiator through 1-stage grafting. Acrylic Acid could intercalate into layers of HPMC and form graft composites through in situ graft-polymerization with acrylic acid and characterized by XRD, FTIR, Thermal spectra and SEM analysis. Swelling property and biodegradability study of the hydrogel graft polymer were investigated. A study of drug loading and drug release with taking the drug Ciprofloxacin is undertaken with this graft polymer using the dissolution apparatus and UV-visible spectrophotometer.
Description: Copyright belongs to proceeding publisher
Appears in Collections:Conference Papers

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