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Title: FTIR Spectroscopic Invitro Drug Interaction Study of Nifedipine Microsphere
Authors: Parida, P
Mishra, S C
Sahoo, S
Keywords: Hypertension
Interaction study
Issue Date: 2012
Publisher: International Journal of Pharmaceutical Studies and Research
Citation: IJPSR/Vol. III/ Issue I/January-March, 2012/XXXX
Abstract: Nifedipine acts as a calcium channel blocker which shows therapeutic values against Hypertension, Angina, and other Cardiac diseases. The present study is to investigate the possibility of developing fingerprinting characteristic of Nifedipine Microsphere by using combined polymer (Ethylcellulose, Polyvinylalcohol) in different proportions required in the formulation of Microsphere for Sustained Release Medication. Solvent evaporation method was used for preparation of Microsphere containing Nifedipine, taking Ethyl cellulose as polymer. Identification of functional group frequencies with the help of Fourier Transform Infrared Spectroscopy has been made. Microspheres are prepared by taking drug to polymer weight ratio of 10:90. From FTIR (400 cm-1 to 4000 cm-1 region) spectroscopic studies were carried out and spectra were used for identification for in-vitro interaction study. It has been found that in Nifedipine Microsphere containing the Dihydropyridine nucleus of the Drug remains unchanged after the formulation which was improved the basic therapeutic activity with sustained release preparation.
Description: Copyright belongs to International Journal of Pharmaceutical Studies and Research
ISSN: E-ISSN 2229-4619
Appears in Collections:Journal Articles

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