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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1582

Title: Spectroscopic Investigations of a Controlled Release Mucoadhesive Suspension
Authors: Sahoo, S
Chakraborti, C K
Behera, P K
Mishra, S C
Keywords: Norfloxacin
HPMC
Mucoadhesive suspension
FTIR
Raman Spectroscopy
Issue Date: 2011
Publisher: Asian Journal of Pharmaceutical and Clinical Research
Citation: Asian Journal of Pharmaceutical and Clinical Research, Vol 4, Suppl 2, 2011
Abstract: Norfloxacin, an antibacterial agent, is having low solubility in aqueous solution. Moreover, the drug possesses short half-life, so frequent dosing is required. To overcome these problems, many investigators have prepared different formulations of Norfloxacin. But till now very few formulations are available from which the drug is absorbed uniformly, so that safe and effective blood level of Norfloxacin could be maintained for a prolonged period. To fulfill this requirement, in the present study, a controlled release drug delivery system was designed and chemical interaction between Norfloxacin and a polymer (HPMC), used in the formulation, was studied by FTIR and Raman Spectroscopy. Ultrasonication method was used for preparation of mucoadhesive Norfloxacin formulation in which drug to polymer weight ratio being 1:5. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 Keywords: Norfloxacin, HPMC, Mucoadhesive suspension, FTIR, Raman Spectroscopy. region) Spectroscopic stu...
Description: Copyright belongs to Asian Journal of Pharmaceutical and Clinical Research
URI: http://hdl.handle.net/2080/1582
ISSN: 0974-2441
Appears in Collections:Journal Articles

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