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http://hdl.handle.net/2080/1571
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| Title: | Formulation and characterization of Chitosan coated PLA/PLGA encapsulated microparticles for vaccine development |
| Authors: | Nayak, B
Routa, P R
Panda, A K
Ray, A R |
| Keywords: | Biodegradable polymers
chitosan coated
PLA/PLGA particles
Microparticles
Chitosan |
| Issue Date: | Nov-2011 |
| Citation: | International conference on Bioengineering and Biotechnology, 28-30 November, 2011, Venice, Italy |
| Abstract: | Thermoplastic aliphatic poly(esters) like
poly(lactide) (PLA), poly(glycolide) (PGA), and especially the copolymer of lactide and glycolide, poly(lactide-co-glycolide) (PLGA) microparticles (MP) have generated immense interest due to their favorable properties such as good biocompatibility, biodegradability, and represent a promising and efficient delivery
system for mucosal vaccination. The surface modification of these polymers and coating with polycationic polymers like chitosan can
produce new formulations with unique properties. Chitosan coatings exhibit an important fraction of primary amino groups to the environment; these amino groups are freely accessible for a variety
of mild coupling reactions for bioactive ligands. The positive charge of chitosan coating likely promotes the ionic binding of nucleic acids, either for gene vaccination purposes, e.g., plasmid DNA or mRNA or to deliver an immunoadjuvant to single-stranded RNA like
in case of delivery of encapsulated rotavi... |
| Description: | Copyright belongs to Proceeding Publisher |
| URI: | http://hdl.handle.net/2080/1571 |
| Appears in Collections: | Conference Papers
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Size | Format |
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| Venice paper.pdf | | 321Kb | Adobe PDF | View/Open |
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