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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1571

Title: Formulation and characterization of Chitosan coated PLA/PLGA encapsulated microparticles for vaccine development
Authors: Nayak, B
Routa, P R
Panda, A K
Ray, A R
Keywords: Biodegradable polymers
chitosan coated
PLA/PLGA particles
Microparticles
Chitosan
Issue Date: Nov-2011
Citation: International conference on Bioengineering and Biotechnology, 28-30 November, 2011, Venice, Italy
Abstract: Thermoplastic aliphatic poly(esters) like poly(lactide) (PLA), poly(glycolide) (PGA), and especially the copolymer of lactide and glycolide, poly(lactide-co-glycolide) (PLGA) microparticles (MP) have generated immense interest due to their favorable properties such as good biocompatibility, biodegradability, and represent a promising and efficient delivery system for mucosal vaccination. The surface modification of these polymers and coating with polycationic polymers like chitosan can produce new formulations with unique properties. Chitosan coatings exhibit an important fraction of primary amino groups to the environment; these amino groups are freely accessible for a variety of mild coupling reactions for bioactive ligands. The positive charge of chitosan coating likely promotes the ionic binding of nucleic acids, either for gene vaccination purposes, e.g., plasmid DNA or mRNA or to deliver an immunoadjuvant to single-stranded RNA like in case of delivery of encapsulated rotavi...
Description: Copyright belongs to Proceeding Publisher
URI: http://hdl.handle.net/2080/1571
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