DSpace@nitr >
National Institue of Technology- Rourkela >
Journal Articles >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1563

Title: Analytical Characterization of a Controlled Release Polymeric Suspension
Authors: Sahoo, S
Chakraborti, C K
Behera, P K
Mishra, S C
Keywords: Carbopol940
FTIR
Mucoadhesive suspension
Norfloxacin
Raman spectroscopy
XRD
Issue Date: 2011
Citation: International Journal of Pharmaceutical Sciences and Research (IJPSR), 2011, Vol. 2, Issue 12
Abstract: Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM) analyses. For interpretation, FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric (Carbopol940) suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, dispersion of particle was studied using SEM techniques. Results: The results from FTIR and Raman Spectroscopic analyses suggested that in the mucoadhesive suspension, carboxylic groups of Norfloxacin and hydroxyl groups of C940 undergo chemical interaction leading to esteri...
Description: Copyright belongs International Journal of Pharmaceutical Sciences and Research (IJPSR)
URI: http://hdl.handle.net/2080/1563
ISSN: 0975-8232
Appears in Collections:Journal Articles

Files in This Item:

File Description SizeFormat
Analytical.pdf921KbAdobe PDFView/Open

Show full item record

All items in DSpace are protected by copyright, with all rights reserved.

 

Powered by DSpace Feedback