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| Title: | Analytical Characterization of a Controlled Release Polymeric Suspension |
| Authors: | Sahoo, S
Chakraborti, C K
Behera, P K
Mishra, S C |
| Keywords: | Carbopol940
FTIR
Mucoadhesive suspension
Norfloxacin
Raman spectroscopy
XRD |
| Issue Date: | 2011 |
| Citation: | International Journal of Pharmaceutical Sciences and Research (IJPSR), 2011, Vol. 2, Issue 12 |
| Abstract: | Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM) analyses. For interpretation, FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric (Carbopol940) suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, dispersion of particle was studied using SEM techniques. Results: The results from FTIR and Raman Spectroscopic analyses suggested that in the mucoadhesive suspension, carboxylic groups of Norfloxacin and hydroxyl groups of C940 undergo chemical interaction leading to esteri... |
| Description: | Copyright belongs International Journal of Pharmaceutical Sciences and Research (IJPSR) |
| URI: | http://hdl.handle.net/2080/1563 |
| ISSN: | 0975-8232 |
| Appears in Collections: | Journal Articles
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| Analytical.pdf | | 921Kb | Adobe PDF | View/Open |
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