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| Title: | Characterization of mucoadhesive ciprofloxacin suspensions by Fourier transform infrared spectroscopy |
| Authors: | Sahoo, S
Chakraborti, C K
Behera, P K
Mishra, S C |
| Keywords: | Ciprofloxacin
C934
C940
HPMC
FTIR
Mucoadhesive Suspensions |
| Issue Date: | Dec-2011 |
| Citation: | International Journal of Pharmaceutical Sciences Review and Research, Volume 11, Issue 2, November – December 2011; Article-025 |
| Abstract: | Ciprofloxacin, an antibacterial agent, is having low solubility in aqueous solution and high rate of absorption from the stomach. It is
precipitated at alkaline pH leading to erratic absorption of the drug from small intestine. To overcome these difficulties, controlled
release mucoadhesive suspensions have been designed so that safe and effective blood level of Ciprofloxacin can be maintained for
a prolonged period. The chemical interaction between Ciprofloxacin and different polymers in suspensions has been studied to know their compatibility by Fourier Transform Infrared Spectroscopy (FTIR). Ultrasonication method was used for the preparation of different formulations, taking Carbopol 934, Carbopol 940 and Hydroxypropyl methyl cellulose polymers. FTIR (400 cm-1 to 4000 cm-1 region) Spectroscopic study was carried out and its spectra were used for interpretation. From the spectral interpretation, it was found that in formulations, the carboxylic groups of Ciprofloxacin and hydroxy... |
| Description: | Copyright for this paper belongs to International Journal of Pharmaceutical Sciences Review and Research |
| URI: | http://hdl.handle.net/2080/1562 |
| ISSN: | 0976044X |
| Appears in Collections: | Journal Articles
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| IJPSRR PUBLISHED ARTICLE.pdf | | 481Kb | Adobe PDF | View/Open |
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