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Title: Qualitative Analysis of a Controlled Release Mucoadhesive Suspension
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Naik, S
Keywords: Ciprofloxacin
Mucoadhesive Suspension
Raman Spectroscopy
Issue Date: 2011
Publisher: International Medical Journal Management and Indexing System
Citation: Int J Novel Drug Deliv Tech 2011:Vol.1:Issue 2
Abstract: Objective:Mucoadhesive polymeric (Carbopol940) suspension of Ciprofloxacin was prepared and optimised with the aim of developing an oral controlled release gastro-retentive dosage form. The qualitative analysis of the formulation was performed by FTIR, Raman Spectroscopy, XRD and SEM analyses. Ultrasonication method was used for the preparation of mucoadhesive Ciprofloxacin suspension. Methods: FTIR [400 cm1 to 4000cm1 region) and Raman (140 to 2400 cm'region) Spectroscopic studies were carried out and spectra were used for interpretation. X-ray powder diffraction data of pure drug, polymer and the formulation were obtained using a powder diffractometer, scanned from a Bragg's angle(20) of 10° to 70° . The dispersion of particle was observed using Scanning electron microscopy techniques. The particle size distribution (PSD) and V> aspect ratio (AR) of particles in the polymeric suspension were obtained from SEM image analysis. Results:The results from FTIR and Raman Spectroscopic analyses suggested that in formulation, the carboxylic groups of Ciprofloxacin and hydroxyl groups of C940 undergo chemical interaction leading to esterification and hydrogen bonding (both intermolecuar and polymeric). The XRD data suggested that the retention of crystalline nature of Ciprofloxacin in the formulation would lead to increase in stability and drug bading; decrease in solubility; and delay in release of the drug from polymeric suspension with better bioavailability and penetration capacity. The SEM image analysis indicated that in the formulation, maximum particles were having aspect ratio from 2 to 4 and standard deviation was very less.
Description: Copyright for this paper belongs to ScopeMed® International Medical Journal Management and Indexing System
ISSN: 2231-4849
Appears in Collections:Journal Articles

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