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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1548

Title: FTIR and Raman Spectroscopic Investigations of Controlled Release Ofloxacin / HPMC Mucoadhesive Suspension
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Keywords: FTIR
Mucoadhesive suspension
Raman Spectroscopy
Issue Date: Jun-2011
Publisher: IJPT
Citation: International Journal Of Pharmacy&Technology| June-2011 | Vol. 3 | Issue No.2 | 2420-2439
Abstract: Ofloxacin, an antibacterial agent, is having low solubility in aqueous solution. Moreover, the drug possesses short half-life, so frequent dosing is required. To overcome these difficulties, many researchers have prepared different formulations of Ofloxacin. But till now very few formulations are available from which the drug is absorbed uniformly, so that safe and effective blood level of Ofloxacin can be maintained for a prolonged period. To fulfill this requirement, in the present study, a controlled release drug delivery system has been designed and chemical interaction between Ofloxacin and polymer in formulation has been studied by FTIR and Raman Spectroscopy. Methods: Ultrasonication method was used for preparation of mucoadhesive Ofloxacin formulation, taking HPMC polymer with drug to polymer weight ratio 1:5. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried out and spectra were used for interpretation. Results: From t...
Description: Copyright belongs to International Journal Of Pharmacy&Technology
URI: http://hdl.handle.net/2080/1548
ISSN: 0975-766X
Appears in Collections:Journal Articles

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