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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1386

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contributor.authorThakur, G-
contributor.authorMitra, A-
contributor.authorRousseau, D-
contributor.authorBasak, A-
contributor.authorSarkar, S-
contributor.authorPal, K-
date.accessioned2011-02-10T04:20:15Z-
date.available2011-02-10T04:20:15Z-
date.issued2011-
identifier.citationJournal of Materials Science: Materials in Medicine (2011) 22:115–123en
identifier.uri10.1007/s10856-010-4185-3-
identifier.urihttp://hdl.handle.net/2080/1386-
descriptionCopyright belongs to Springeren
description.abstractHydrogels are extensively studied as carrier matrices for the controlled release of bioactive molecules. The aim of this study was to design gelatin-based hydro-gels crosslinked with genipin and study the impact of crosslinking temperature (5, 15 or 25oC) on gel strength, microstructure, cytocompatibility, swelling and drug release. Gels crosslinked at 25oC exhibited the highest Flory–Rehner crosslink density, lowest swelling ratio and the slowest release of indomethacin (Idn, model anti-inflammatory drug). Diffusional exponents (n) indicated non-Fickian swelling kinetics while drug transport was anomalous. Hydrogel biocompatibility, in vitro cell viability,cell cycle experiments with AH-927 and HaCaT cell lines indicated normal cell proliferation without any effect on cell cycle. Overall, these results substantiated the use of genipincrosslinked hydrogels as a viable carrier matrix for drug release applications.en
format.extent643110 bytes-
format.mimetypeapplication/pdf-
language.isoen-
publisherSpringeren
subjectCrosslinkingen
subjectHydrogelsen
subjectDrugen
titleCrosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitroen
typeArticleen
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