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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1372

Title: FTIR and Raman Spectroscopy as a Tool for Analyzing Sustained Release Hydrogel of Ciprofloxacin/Carbopol Polymer
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Naik, S
Nanda, U N
Keywords: Cipro
Raman Spectroscopy
Issue Date: Jan-2011
Publisher: International Journal of Pharmaceutical Sciences and Research
Citation: IJPSR (2011), Vol. 2, Issue 2
Abstract: Ciprofloxacin, an antibacterial agent, is having low solubility in aqueous solution and high rate of absorption from the stomach. It is precipitated at alkaline pH which leads to erratic absorption of the drug from small intestine. To overcome these difficulties, many researchers have prepared different formulations of Ciprofloxacin. But till now very few formulations are available from which the drug is absorbed uniformly, so that safe and effective blood level of Ciprofloxacin can be maintained for a prolonged period. To fulfill this requirement, in the present study, a sustained release drug delivery system (hydrogel) has been designed and chemical interaction between Ciprofloxacin and polymer in hydrogel has been studied by FTIR and Raman Spectroscopy. Methods: Ultrasonication method was used for preparation of hydrogel of the Ciprofloxacin, taking Carbopol 934 polymer with drug to polymer weight ratio 1:5. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spe...
Description: Copyright belongs to International Journal of Pharmaceutical Sciences and Research.
URI: http://hdl.handle.net/2080/1372
ISSN: 0975-8232
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