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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1371

Title: Scanning Electron Microscopy as an Analytical Tool for Particle Size Distribution and Aspect Ratio Analysis of Ciprofloxacin Mucoadhesive Polymeric Suspension
Authors: Sahoo, S
Chakraborti, C K
Mishra, S C
Nanda, U N
Keywords: Cipro
mucoadhesive formulation
Issue Date: Jan-2011
Publisher: Academic Research Publishing Agency
Citation: IJRRAS 6 (1) January 2011
Abstract: Two types of mucoadhesive suspension of Ciprofloxacin were formulated by taking Carbopol934 and Carbopol940 polymers. The morphologies and mechanical properties of the resultant formulations were investigated. The dispersion of particle was observed using Scanning electron microscopy (SEM) techniques. The particle size distribution (PSD) and aspect ratio (AR) of particles in the polymeric suspension were obtained from SEM image analysis. It was found that SEM imaging displays directly the micron level dispersion of particles in polymeric formulation. The technique has significant potential for characterizing such formulation, having some advantages over „traditional‟ transmission electron microscopy in terms of generating representative data in a realistic timescale. Considering graphical analysis, the maximum particle size range for formulation containing Cipro and C934 is between 10 and 15 μm but in case of Cipro and C940, it is 5 to 10 μm. In the rod-like particles whose shapes are ...
Description: Copyright belongs to Academic Research Publishing Agency.
URI: www.arpapress.com/Volumes/Vol6Issue1/IJRRAS_6_1_11.pdf
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