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Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/1276

Title: Development and Characterization of Chitosan based Polymeric Hydrogel Membranes
Authors: Ray, M
Pal, K
Anis, A
Banthia, A K
Keywords: cationic polymer,
membrane,
polyelectrolyte,
cytocompatibility.
Issue Date: 2010
Publisher: VSP, an imprint of Brill
Citation: Designed Monomers & Polymers, Volume 13, Number 3, 2010, pp. 193-206(14)
Abstract: The current study deals with the development of glutaraldehyde crosslinked chitosan-based delivery system with improved mechanical properties utilizing reactive solvent technique. The prepared systems were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), thermo gravimetric analysis (TG) and differential scanning calorimetry (DSC). The systems were also analysed for mechanical and pH-dependent swelling properties and they were also analysed for their hemocompatibility and cytocompatibility. FTIR studies indicated formation of imine bonds during the crosslinking reaction of chitosan and glutaraldehyde. The thermal, XRD and mechanical studies indicated optimal properties for the system prepared with 5% methacrylic acid as reactive solvent. The developed systems indicated pH-dependent swelling behaviour with increased swelling at lower pH. The prepared delivery systems were found to be highly hemocompatible in the presence of human blood and cytocom...
URI: http://hdl.handle.net/2080/1276
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