Investigation on DNMT1 Orchestrated-G2/M Transition and Chromatin Segregation by Interaction with MKI67 and CDK1 in Lung Adenocarcinoma Cells See

Background: According to the prevailing views, the chromatin organization pattern influences the microenvironment of a gene within a chromosome; transcription factors and epigenetic modifications of chromatin dictate the possibility of its expression and progression through the cell cycle. Gene expression mechanisms and their relationship with cell cycle dynamics remain unexplored till today. The theoretical background and conceptual logics suggest that epigenetic modifications, specifically ...

Liquid-Liquid Phase Separation Links Cholesterol Biosynthesis Inhibition to DNMT1-UHRF1 Condensate formation and Epithelial-to-Mesenchymal Transition Reversal in Colon Adenocarcinoma Cells See

Background: Over the last two decades, liquid-liquid phase separation (LLPS) has emerged as a state-of-the-art biochemical phenomenon in modern cancer research, precisely enabling spatio-temporal coordination across biochemical processes crucial for epigenetic choreography associated with gene expression. Among several epigenetic alterations, DNA methylation is the most crucial reversible DNA modification, which dictates the possibility of gene expression and chromatin organization. Methods: ...

Deciphering the Genotoxic Mechanisms of Plumbagin: A Natural Product Lead for Translational Targeting of DNA Damage Pathways in Lung Cancer See

Natural products continue to play a pivotal role in anticancer drug discovery. In this study, we investigated the mechanistic and translational potential of plumbagin, a bioactive naphthoquinone isolated from Plumbago zeylanica, in non-small cell lung cancer (NSCLC). The objective was to delineate whether plumbagin induces DNA damage through direct DNA interaction or via alternative molecular mechanisms, and to evaluate its potential as a genotoxic lead compound. Cytotoxicity assays demonstra...

Advanced Control of Single-Phase Grid-Tied SPGU-BSU Systems for DC Offset Mitigation and Power Quality Enhancement See

The power system faces several difficulties when a PV array and nonlinear household loads are connected to the main stream. It affects both power quality and grid synchronization during grid-connected and stand-alone modes. Furthermore, the addition of more power electronics devices affects both the grid voltage and current. To mitigate the above issues, this article proposes an integrated setup of a solar power generation unit (SPGU) and a battery storage (BS) system as a distributed energy ...

Green Extraction of High-Quality Protein from Cassava Leaves Using Deep Eutectic Solvents: Nutritional and Functional Comparison with Alkaline Extraction See

Cassava (Manihot esculenta) leaves, rich in protein content ranging from 20–30% and abundant in essential amino acids (EAAs), represent a valuable and sustainable source of plant-based protein alternatives. Deep eutectic solvents (DESs) represent a promising green alternative to conventional alkaline extraction- isoelectric precipitation (AE-IP) for recovering plant proteins with minimal denaturation. In this study, eight different DESs formations were evaluated for extracting protein from de...

Enhanced Preservation of Chicken Meat Using Curcuma Extract-Loaded Gelatin/Chitosanlactate Films Reinforced with Cellulose Nanoparticles See

This study presents the development of multifunctional biocomposite films consist of gelatin (GE), chitosan-lactate (CL), curcuma ethanolic extract (CEE), and cellulose nanoparticles (CNP) for potential application in active food packaging. The incorporation of CNP at different concentration aimed to reinforce the structural network within the polymer matrix and enhance the thermal, physicochemical, barrier, and functional properties of the films. The addition of CNP increased the compatibili...

Low-Frequency Noise as A Probe of Microscopic Disorder in CVD-Grown Graphene See

We investigate low-frequency resistance fluctuations (1/f noise) in large-area graphene synthesized by chemical vapor deposition (CVD). The magnitude of the noise in CVD-grown graphene is found to be several orders of magnitude higher than that typically observed in mechanically exfoliated single-crystal graphene. This enhanced noise level is attributed to the presence of structural disorder inherent to polycrystalline CVD films, including grain boundaries and defect states. Temperature-depen...

UCRS: Uncertainty-Calibrated Region Sampling for Real-Time Small Object Detection in High-Resolution Images See

The detection of objects in high-resolution (HR) images, particularly those taken by surveillance systems or unmanned aerial vehicles (UAVs), appears to be a significant computational bottleneck. Additionally, I observe that when traditional methods process the entire input domain uniformly, the inherent sparsity of objects in backgrounds results in a great deal of redundancy. The Uncertainty-Calibrated Region Sampling (UCRS) framework is presented in this paper. The inefficiency is addressed...

Plasma-Engineered Plantain Peel (Musa paradisiaca) Starch Films: Enhancement of Mechanical, Thermal and Barrier Properties See

Food packaging is an essential component to protect, preserve and handle the food from extrinsic factors. Plastic has been used as a packaging material because of its durability, versatility, light weight, cost-effectiveness and water resistance properties. There are different types of plastic such as high-density polyethylene (HDPE), low density polyethylene (LDPE), polypropylene (PP), polystyrene (PS) and polyethylene terephthalate (PET). However, the detrimental impact of synthetic plastic...

Bio-Based Nanocomposite Films Prepared from Tamarind Seed Xyloglucan and Seed Coat–Derived Carbon Dots See

Since India is the major tamarind producer in the world, the current research focuses on tamarind kernel xyloglucan (XG) as a biodegradable polymer backbone in the fabrication of multifunctional nanocomposite films. The tamarind seed coat biomass was converted into carbon dots (CDs) and added into the XG matrix in different concentrations (1-5% w/w) to enhance functionality of films. The fluorescence spectroscopy was used to characterize the synthesized CDs. The structural, mechanical, barrie...

Reduction Kinetics Study of Mill Scale Waste Using Low-Grade Thermal Coal for The Production of Pure Iron See

Mill scale, a by-product from hot rolling processes, offers high iron content but poses handling and recycling challenges due to its fine particle size and tendency to oxidize. This present study investigates the reduction behavior of mill scale pellets in both carbonaceous (low-grade thermal coal) and non-carbonaceous atmosphere (N2 and H2) using as reductant, emphasizes reduction efficiency, microstructural and phase evolution, and reaction kinetics. Mill scale, a major iron oxide-rich by-p...

Development of Oxide Dispersion Strengthened Mo Alloys by Mechanical Alloying and Hydrogen Sintering See

Molybdenum-based alloys are highly valued for their elevated melting points, excellent mechanical properties like yield strength, higher thermal conductivity, which make them crucial for high-temperature application such in aerospace, defence and nuclear sectors where maintaining strength and structural integrity is very essential. Nevertheless, Mo also faces some drawbacks, such as brittleness at room temperature and rapid oxidation at elevated temperatures, which can lead to failure, necess...

A Study on Object Detection and Tracking by Millimeter Wave FMCW Radar See

This paper presents a complete FMCW radar based target tracking system using the TI AWR1843 mmWave sensor and DCA1000EVM. Real radar data captured through mmWave Studio, along with synthetically generated FMCW signals, are processed in MATLAB for controlled evaluation. A walking human target is tracked using range, Doppler, and angle estimation, followed by alpha-beta and Kalman filtering to obtain position, velocity, and trajectory. Performance metrics such as range RMSE, angle RMSE, Cartesi...

Observation of a Second Dirac Point in A Graphene/Superconductor Bilayer See

Two-dimensional (2D) materials have attracted vast research interest since the breakthrough discovery of graphene. One major benefit of such systems is the ability to tune the Fermi level through the charge neutrality point between electron and hole doping. In this presentation, we show that single layer graphene coupled to the low-density superconductor indium oxide (InO) exhibits two charge neutrality points, each of them representing electronic regions in which the carrier density can be t...

Statistical Inference of a Chen Lifetime Competing Risks Model Based On Improved Adaptive Type-II Progressive Censored Data See

This paper studies different failure modes for endurance of insulation of electrodes under high voltage stress. A competing risks model is studied under improved adaptive type-II progressive censoring scheme (IAT-II PCS) referring to this phenomena. Two independent competing causes of failure are considered where lifetime of these failures are assumed to follow Chen distribution with unknown scale and shape parameters. Maximum likelihood estimators (MLEs) of the unknown parameters are derived...

Sustainable Destination Branding: A Paradigm Shift in Resilient Tourism Features See

Sustainable destination branding authentically communicates a destination's unique character while prioritizing environmental stewardship, social equity, and economic resilience This extended abstract synthesizes academic theories, key principles, actionable strategies, and current challenges, and proposes a forward looking agenda for theory and practice Integrating contemporary literature, stakeholder centered methodology, and critical perspectives including post colonial critiques this work...

CNN-Based Fault Classification in Side-Channel Power Traces with Robust Preprocessing and Regularization See

Side-channel attacks are carried out by observing physical leakages such as power, timing, or electromagnetic emissions, and these leakages often reveal information about the internal operations of a cryptographic device. In this work, synthetic power-trace data with controlled fault patterns was generated so that the behavior of different machine learning models could be studied under a variety of fault conditions. Several types of artificial disturbances were injected into the traces using ...

Fabrication of Bi-Phasic Silk Fibroin/Chitosan/ 52S4.6 Bioactive Glass and Nanofibrous Gelatin-Based Macroporous Scaffold Aimed at Osteochondral Tissue Regeneration See

The development of a biphasic scaffold that simultaneously supports cartilage and subchondral bone regeneration is a very promising approach towards effective osteochondral tissue engineering. In this study, 15 wt% of 52S4.2 nanobioactive glass (NBG) incorporated silk fibroin (SF), chitosan (CH) based porous scaffold (SF 80 /CH 20 /NBG 15 ) was fabricated via a freeze-drying technique, providing a supportive bulk structure mimicking subchondral bone and then electrospun nanofibrous gelatin (G...

AtATG6-Mediated Cell Death in Arabidopsis Confers Immunity Against Magnaporthe oryzae See

Magnaporthe oryzae can infect rice, however, Arabidopsis is a nonhost that actively fights the infection. Despite the discovery of numerous genes and QTLs, rice blast has not been cured. In order to protect Arabidopsis against rice blast, the non-host resistance (NHR) mechanism triggers the hypersensitive response (HR), a type of localized programmed cell death associated with pathogen limiting or killing that results in resistance to pathogenic infections. Cell death is generally thought to ...