Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4582
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLalruatfela, Anthony-
dc.contributor.authorBiswal, Priyajit-
dc.contributor.authorMallick, Bibekanand-
dc.date.accessioned2024-06-04T06:27:53Z-
dc.date.available2024-06-04T06:27:53Z-
dc.date.issued2024-05-
dc.identifier.citation12th RNA Group Meeting, IIT GUWAHATI, 22-24 May 2024en_US
dc.identifier.urihttp://hdl.handle.net/2080/4582-
dc.descriptionCopyright belongs to proceeding publisheren_US
dc.description.abstractThe rise of tumor recurrence and incomplete remission in cancer treatment can primarily be attributed to gradual loss of drug sensitivity and/or the increase in chemoresistance. Consequently, this presents a serious threat to public health, potentially triggering a global crisis. Fortunately, the advent of advanced molecular techniques has unraveled small noncoding RNAs which are known regulators of oncogenic events to also prompt sensitivity towards chemo drugs. As such, our lab has deciphered piRNAs in different solid tumors and established their mechanisms of action in tumorigenesis including its role in chemoresistance. In the present study, we reported that piR-hsa-30937 sensitizes tongue cancer to cisplatin by regulating cell proliferation, apoptosis, and ROS production. Further, GAB2 is predicted as the target of piR-hsa-30937 whose expression drastically reduced upon transient overexpression of this piRNA. Moreover, cisplatin treatment increased the expression of piRhsa-30937 several folds, the rationale of which is being investigated. Altogether, this study might pave way towards piRNA-target based therapeutics to wrestle chemoresistance in cancer.en_US
dc.subjectPIWI‐interacting RNAen_US
dc.subjectpiR-hsa-30937en_US
dc.subjectGAB2en_US
dc.subjectcisplatinen_US
dc.subjecttongue canceren_US
dc.titlePIWI-RNA sensitizes tongue cancer cells to cisplatinen_US
dc.typePresentationen_US
Appears in Collections:Conference Papers

Files in This Item:
File Description SizeFormat 
2024_12thRNGroup_ALalruatfela_PIWI-RNA.pdf857.87 kBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.