Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4417
Title: Vicinal-diols as Promoters in MBH Reaction: An Efficient Protocol for Scantly Reported Aliphatic Aldehydes
Authors: Mandal, Sukanya
Panda, Jeetendra
Sahoo, Gokarneswar
Keywords: Vicinal-diols
MBH Reaction
Aldehydes
Issue Date: Feb-2024
Citation: 32nd CRSI National Symposium in Chemistry (CRSI-NSC-32) and CRSI-RSC Symposium, BITS Pilani, 1-4 February 2024
Abstract: This work proposes an integrated strategy to mitigate the sluggishness of sp 2 -C electrophiles, particularly aliphatic aldehydes, in MBH reactions with various pro-nucleophiles. 1,2-diols have been found to activate MBH precursors, enabling a faster, more efficient approach with an array of substrate scope, particularly for rarely reported aliphatic aldehydes as electrophile. The in-situ transesterification of the MBH adduct with glycol provided direct access to bioactive natural compounds against Leishmania Proteases.
Description: Copyright belongs to proceeding publisher
URI: http://hdl.handle.net/2080/4417
Appears in Collections:Conference Papers

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