Vicinal-diols as Promoters in MBH Reaction: An Efficient Protocol for Scantly Reported Aliphatic Aldehydes

Abstract

This work proposes an integrated strategy to mitigate the sluggishness of sp 2 -C electrophiles, particularly aliphatic aldehydes, in MBH reactions with various pro-nucleophiles. 1,2-diols have been found to activate MBH precursors, enabling a faster, more efficient approach with an array of substrate scope, particularly for rarely reported aliphatic aldehydes as electrophile. The in-situ transesterification of the MBH adduct with glycol provided direct access to bioactive natural compounds against Leishmania Proteases.