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http://hdl.handle.net/2080/4381| Title: | A Plant Extract-Based, Non-Invasive, Drug-Free Wound Dressing for Treating Bacterial Infections with Enhanced Wound Healing |
| Authors: | Mohanty, Ananya Pattnayak, Bibek chaw Behera, Lingaraj Mohaptra, Sasmita |
| Keywords: | nitric oxide GSNOCD-OS@PA antibacterial wound healing biofilm reduction |
| Issue Date: | Jan-2024 |
| Citation: | 37th Annual Conference of Orissa Chemical Society & National Conference on Molecules to Materials (MTM-2024), Ravenshaw University, Cuttack, Orissa, India, 04 January 2024 |
| Abstract: | A multifunctional hydrogel was designed by integrating the photothermal carbon dot with a NO-releasing moiety (GSNOCD) within an oxidized sodium alginate conjugated polyacrylamide (OS@PA) matrix to enhance wound healing along with removal of bacterial infections during the healing process. The novel hydrogel patch showed unique features like skin adhesion, self-healing, on-demand removability, biocompatibility, high photothermal efficiency (47.1% ), and NIR-controlled NO release (31.7 mg/L, 808nm, 10 min). The synergetic effect of NO gas therapy and photothermal therapy under 808nm laser successfully reduced the viability of both Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) to 3 and 5%, respectively with effective fibroblast proliferation in a cell scratch assay |
| Description: | Copyright belongs to proceeding publisher |
| URI: | http://hdl.handle.net/2080/4381 |
| Appears in Collections: | Conference Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2024_OCS_AMohanty_APlant.pdf | Poster | 1.08 MB | Adobe PDF | View/Open Request a copy |
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