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Title: | Investigating the Physicochemical Properties of Oxoanion Doped Iron Mineral: Implication in Understanding the Ferritin Iron Core |
Authors: | Subudhi, Tanaya Behera, Rabindra Kumar |
Keywords: | Ferritin Iron Core Iron Mineral |
Issue Date: | Dec-2023 |
Citation: | International Conference on Modern Trends in Inorganic Chemistry, Indian Institute of Science, Bengaluru, India, 14-17 December 2023 |
Abstract: | Iron, a crucial element, is inextricably intertwined in various stages of living and non-living systems. Its existence in two different oxidation states (Fe 2+ /Fe 3+ ) is not only a virtue but also troublesome (low solubility of Fe3+ at neutral pH and Fenton’s reaction by Fe 2+ ). As a solution to this essentiality and toxicity dilemma, nature devised a globular multimeric protein nanocage: ferritin, to detoxify and store iron in soluble ferrihydrite (Fh) bio-mineral form. Native ferritin bio-minerals are associated with variable amounts of phosphate depending upon their source (animals Pi: Fe ~0.1 & plant and bacteria Pi: Fe ~0.5 -1.0) which possibly contributes to their physicochemical properties. Whether the occurrence of a high Pi : Fe ratio in plant/bacterial ferritins is just a coincidence or a consequence of favorable ferritin pore electrostatics is not well understood. Similar to phosphate other oxoanions may stabilize Fe 3+ to modulate the redox and optoelectronic properties of bare and ferritin-encapsulated ferrihydrite minerals. Therefore, a comparison of bare and protein-encapsulated oxoanion-doped iron minerals may give insights into the impact of oxoanion on the structure, stability, and reactivity of iron bio-mineral. So a detailed investigation was performed on a number of oxoanion-doped Ferrihydrite which closely resembles, the iron mineral found in nature. Hence, the current work justifies the % incorporation of oxoanion by natural selection. |
Description: | Copyright belongs to proceeding publisher |
URI: | http://hdl.handle.net/2080/4355 |
Appears in Collections: | Conference Papers |
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2023_MTIC_TSubudhi_Investigating.pdf | Poster | 2.78 MB | Adobe PDF | View/Open Request a copy |
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