Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4259
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dc.contributor.authorGhosh, Sayantan-
dc.contributor.authorNayak, Bismita-
dc.date.accessioned2024-01-08T10:07:45Z-
dc.date.available2024-01-08T10:07:45Z-
dc.date.issued2023-12-
dc.identifier.citation92nd Annual Meet of the Society of Biological Chemists(SBC) BITS Pilani, 18-20th Dec 2023en_US
dc.identifier.urihttp://hdl.handle.net/2080/4259-
dc.descriptionCopyright belongs to proceeding publisheren_US
dc.description.abstractGlioblastoma is the most severe form of malignant brain tumor with a mean survival rate of 12–15 months, attributed to its poor prognosis and scarce treatment alternatives. Also, the poor response and resistance to conventional radiotherapy and chemotherapy of GBM demand for the development of innovative and effective treatment modalities. Nature-derived compounds have grasped significant attention as a promising alternative for the development of novel anti-cancer drugs. Berberine is a naturally occurring isoquinoline alkaloid that is extracted as a sulfate salt from the stem bark, rhizomes, and roots of Berberidaceae. Here, we have investigated Berberine role in inhibiting cell proliferation and migration in LN229 and U87MG brain cancer cells. Also we have investigated the ROS producing ability and Mitochondria membrane disrupting ability in LN229 and U87MG brain cancer cells. Berberine decreased the cell viability in LN229 and U87MG brain cancer cells in a dose and time dependent manner. The present study aims to investigate the epigenetic regulation of Nrf2 gene in the presence of berberine in glioblastoma.en_US
dc.subjectBerberineen_US
dc.subjectBrain tumor targetingen_US
dc.subjectROS Productionen_US
dc.subjectMitochondria Membraneen_US
dc.subjectPermeabilizationen_US
dc.subjectCell cycle arresten_US
dc.titleBerberine Augments Apoptosis by Producing ROS and Disrupting MMP via Regulating Nrf2 Signalling Pathway in Glioblastoma Cell lineen_US
dc.typePresentationen_US
Appears in Collections:Conference Papers

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