Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4228
Title: Nonequilibrium Switching of Segmental States Can Influence Compaction of Chromatin
Authors: Sahoo, Soudamini
Keywords: Nonequlibrium switching
Chromatin organization
Issue Date: Dec-2023
Citation: 17th CompFlu International Conference, IIT Madras, Tamil Nadu, 16-20 December 2023
Abstract: Knowledge about the dynamic nature of chromatin organization is essential to understand the regulation of processes like DNA transcription and repair. While most models assume protein organization and chemical states along chromatin as static, experiments have shown that these are dynamic and lead to the switching of chromatin segments between different physical states. To understand the implications of this inherent nonequilibrium switching, we present a diblock copolymer model of chromatin, with switching of its segmental states between two states, mimicking active/repressed or protein unbound/bound states. We show that competition between switching timescale Tt , polymer relaxation timescale τp , and segmental relaxation timescale τs can lead to non-trivial changes in chromatin organization, leading to changes in local compaction and contact probabilities. Radius of gyration of chromatin shows a non-monotonic behavior with Tt. We find that polymers with a small segment length (Ns) exhibit a more compact structure than those with larger segment lengths. Also, we observe that the switching can lead to higher contact probability and better mixing of far-away segments
Description: Copyright belongs to proceeding publisher
URI: http://hdl.handle.net/2080/4228
Appears in Collections:Conference Papers

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