Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4211
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dc.contributor.authorOjha, Monalisha-
dc.contributor.authorYadav, Kanti Kusum-
dc.contributor.authorPariary, Ranit-
dc.contributor.authorArakha, Manoranjan-
dc.contributor.authorBhunia, Anirban-
dc.contributor.authorJha, Suman-
dc.date.accessioned2024-01-02T11:31:30Z-
dc.date.available2024-01-02T11:31:30Z-
dc.date.issued2023-12-
dc.identifier.citation92nd Annual Meet of the Society of Biological Chemists(SBC) BITS Pilani, 18-20th December 2023en_US
dc.identifier.urihttp://hdl.handle.net/2080/4211-
dc.descriptionCopyright belongs to proceeding publisheren_US
dc.description.abstractZinc oxide nanoparticle with negative surface potential (ZnONP) enhances bovine insulin fibrillation. Here, we are exploring ZnONP with positive surface potential (ZnONPUnc) and surface functionalized with tyrosine and tryptophan amino acids to observe the effects of surface potential and surface functional groups on the fibrillation. ZnONPUnc, despite of inversed surface potential, enhances the insulin fibrillation with increase in the interface concentration at physiological pH. Whereas, the interface moderation with the amino acids mitigates the surface-mediated insulin fibrillation propensity. Additionally, the study indicates that the change in interfacial functional groups at ZnONPUnc significantly reverses the interface-mediated destabilization of insulin conformation. The functional groups from the amino acids, C=O, N-H and aromatic functional groups, are anticipated to further stabilize the insulin conformation by forming hydrogen bond and van der Waals interactions with the key amyloidogenic sequences of insulin, A13-A20 from A-chain and B9-B20 from B-chain. Hence, the altered interaction profile, with change in interfacial functional groups, mitigates the interface-mediated insulin fibrillation and the ZnONPUnc-/fibril-mediated cytotoxicity.en_US
dc.subjectInsulinen_US
dc.subjectFibrillationen_US
dc.subjectNanoparticle surface functionalizationen_US
dc.subjectZnONPen_US
dc.subjectCytotoxicityen_US
dc.titleZinc Oxide Nanoparticle Interface Moderation with Tyrosine and Tryptophan Reverses the Pro-amyloidogenic Property of the Particleen_US
dc.typePresentationen_US
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