Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/4203
Title: Corona of Biologically Synthesized Nanoparticle Provide Better Interface to Trap Monomeric Α-Synuclein in Non-Cytotoxic Amorphous Aggregate Structure
Authors: Jena, Sonali
Jha, Suman
Keywords: Corona
α-synuclein
Issue Date: Dec-2023
Citation: 92nd Annual Meet of the Society of Biological Chemists(SBC) BITS Pilani, 18-20th Dec 2023
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by the degeneration of dopaminergic neurons in the substantia nigra and the abnormal accumulation of Alpha-synuclein (α-syn) aggregates or Lewy bodies, leading to a major loss of motor function. α-Syn is an intrinsically disordered protein, involved in vesicular trafficking and neurotransmitter release. The aggregation of α-syn involves a cascade of structural transition from monomeric protein to the fibrillar form of protein, which is known to be a complex process and is regulated by several intrinsic and extrinsic factors. Currently, nanoparticles have been reported for easy drug delivery as they can easily pass the blood-brain barrier. There are several reports suggesting that the interfaces of metal oxide nanoparticles have a direct effect on α-syn conformation, and it can inhibit the protein amyloidogenesis. Hence, in this report, we screen different ZnONP interfaces (chemically and biologically synthesized) with anti-amyloidogenic potential for α-syn
Description: Copyright belongs to proceeding publisher
URI: http://hdl.handle.net/2080/4203
Appears in Collections:Conference Papers

Files in This Item:
File Description SizeFormat 
2023_SBC_SJena_Corona.pdf2.07 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.