Reduced Graphene Oxide with Titanium Oxide-Based Nanocomposite for Regenerative Medical Application

Abstract

The primary aim of this study is to synthesize reduced graphene oxide based nanocomposite for wound healing applications. Reduced graphene oxide with titanium oxide nanocomposite was synthesis by one-step hydrothermal method [1]. The sol-gel method was utilized to synthesize Titanium dioxide nanoparticles (TNPs) and graphene oxide was synthesized by the improved hummer’s method [2]. The graphene oxide was thermally reduced into reduced graphene oxide. The reduced graphene oxide with titanium oxide nanocomposite was physiochemical characterized by the transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR), Raman spectra and zeta potential. The average particles size of TNPs is 13 nm obtain from TEM images. The XRD reveals the TNPs were in nanocrystalline anatase phase. The characteristics peak of Ti-O-Ti bonds was observed between 400 to 850 cm-1 in the Fourier transforms infrared spectrum. Reduced graphene oxide was confirmed from the Fourier transforms infrared spectrum. The Raman spectra of nanocomposite material show the peaks at 1349 cm-1 correlate to the D bands and peaks at 1597 cm-1 correlate to the G bands. Also, the in-vitro scratch assay for shows wound closer time ob0f 48 h. Thus the nanocomposite is a potential material for wound healing.