Please use this identifier to cite or link to this item:
http://hdl.handle.net/2080/3734
Title: | Papaya-Derived Carbon-Dot-Loaded Fluorescent Hydrogel for NIR-Stimulated Photochemotherapy and Antibacterial Activity |
Authors: | Panda, Snigdharani Pattnayak, Bibek Chaw Dash, Priyanka Nayak, Bismita Mohapatra, Sasmita |
Keywords: | hydrogel photodynamic eactive oxygen species (ROS) nanodrug |
Issue Date: | Aug-2022 |
Citation: | 161st Birth Anniversary Acharya P. C. Ray & International Seminar on Recent Advances in Chemistry and Material Science (RACMS – 2022) |
Abstract: | The improper use of antibiotics results in the emergence of drugresistant microbes which is a serious concern to public health. Here, an NIRstimulated fluorescent antibacterial gel has been formulated by encapsulating papaya leaf-derived carbon dots (PCQDs) in a thermosensitive PVA-melamine hydrogel. This antibacterial gel can release anticancer drug 5-Fu in a spatiotemporal and dosage-controlled manner under the exposure of a 980 nm NIR laser. PCQDs can precisely generate the photothermal effect and reactive oxygen species (ROS) under NIR which induce a significant antibacterial activity in both Gram-positive and Gram-negative bacteria in a controlled manner. At the same time, a customized delivery of 5-Fu minimizes the side effect of the drug. Consequently, this innovatively designed fluorescent gel exhibited an antimicrobial effect and can act as a promising material for the NIR-responsive release of anticancer drug 5-Fu as demonstrated in B16F10 melanoma cells |
Description: | Copyright belongs to proceeding publisher |
URI: | http://hdl.handle.net/2080/3734 |
Appears in Collections: | Conference Papers |
Files in This Item:
File | Description | Size | Format | |
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pattanakiB_RACMS0222.pdf | 1.12 MB | Adobe PDF | View/Open |
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