Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/3703
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dc.contributor.authorSahu, Gurunath-
dc.contributor.authorPattanayak, Pratikshya Das-
dc.contributor.authorMohapatra, Deepika-
dc.contributor.authorDinda, Rupam-
dc.date.accessioned2022-07-28T11:24:24Z-
dc.date.available2022-07-28T11:24:24Z-
dc.date.issued2022-07-
dc.identifier.citationCRSI NSC-29th conference 2022 organized by IISER Mohali, Chandigarh. June 7-9, 2022en_US
dc.identifier.urihttp://hdl.handle.net/2080/3703-
dc.descriptionCopyright belongs to proceeding publisheren_US
dc.description.abstractIn this work, one oxidomethoxidovanadium(V) [VVO(L)(OMe)] (1) and two mixed-ligand oxidovanadium(IV) [VIVO(L)(phen)] (2), and [VIVO(L)(bipy)] (3) complexes have been synthesized using a tridentate bi-negative ONS donor dithiocarbazate as main ligand, H2L [where, H2L = S-benzyl-3-(2-hydroxy-3-ethoxyphenyl)methylenedithiocarbazate] along with 1,10-phenanthroline (phen) (for 2) and 2,2′-bipyridine (bipy) (for 3) as co-ligands. The ligand and complexes have been characterised by FT-IR, UV-vis, NMR, and HR-ESI-MS techniques. Distorted square pyramidal for 1, and distorted octahedral geometry for 2 and 3 was confirmed by single crystal X-ray crystallography. The behavior of 1−3 in solution medium has been investigated through various physicochemical techniques.1 It is observed that 1 completely and 2−3 partially decomposes and converts into a penta-coordinated species, [VIVO(L)(DMSO/H2O)] after the release of the methoxido group (1) or breaking of the diimine based co-ligands (2 and 3) in DMSO/aqueous solution. Interestingly, in DMSO/aqueous solution, 1 gets completely reduced and converted into the corresponding oxidovanadium(IV) species.2 Interaction of 1−3 with calf thymus DNA (CTDNA) was investigated1 and the results show, complex 2 exhibited the maximum binding constants, Kb = 7.12 × 104 M−1. The anticancer potential of 1−3 was evaluated1,3 by cell viability assay against human breast carcinoma cell, MCF-7, and noncancerous mouse embryonic cell, NIH-3T3 and 2 was found to be the most cytotoxic complex (IC50 = 6.73 ± 0.36 M) in the series. In addition, 2 selectively inhibit colony formation compared to the rest complexes. Also, the cell cycle studies of the complexes were performed using flow cytometry analysis.3en_US
dc.subjectoxidomethoxidovanadiumen_US
dc.subjectcytometry analysisen_US
dc.titleDithiocarbazate based oxidomethoxidovanadium(V) and mixed-ligand oxidovanadium(IV) complexes: Study of solution behavior, DNA binding, and anticancer activityen_US
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