Please use this identifier to cite or link to this item: http://hdl.handle.net/2080/3392
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dc.contributor.authorAnsari, Aafreen-
dc.contributor.authorBharti, Deepti-
dc.contributor.authorRathnam, V Shanmuga Sharan-
dc.contributor.authorBanerjee, Indranil-
dc.date.accessioned2019-12-18T05:49:39Z-
dc.date.available2019-12-18T05:49:39Z-
dc.date.issued2019-11-
dc.identifier.citationInternational Conference on Biomaterial -Based Therapeutic Engineering and Regenerative Medicine (BIOTERM 2019) Kanpur, India, 28 November - 01 December2019en_US
dc.identifier.urihttp://hdl.handle.net/2080/3392-
dc.descriptionCopyright of this document belongs to proceedings publisher.en_US
dc.description.abstractBiomedical applications of carbon nanotubes often faced serious criticism because of its nanotoxicity. Its been observed that CNT showed hepatotoxicity in vitro at the concentration above 20µg/ml but its effect on liver cells at lower concentrations is not yet explored. Here, we performed a detailed study to evaluate the dose-dependent response of hepatocytes against CNT. For this purpose hepatocytes cell line (HepG2) were treated with multi-wall CNT (MWCNT) of different concentration ranging 100µg/ml to 10ng/ml. MWCNT at a concentration of 100µg/ml showed hepatotoxicity but at lower concentrations, it stimulate cell proliferation. LDH assay revealed that MWCNT at higher concentration caused significant damage to the cell membrane but at lower concentration, it fails to do so. It was observed that MWCNT at lower concentration increases production of albumin, ATP7B and SULT2A1. Density of bile canaliculi in HepG2 cells also increased after treatment. These studies altogether suggest that although MWCNT showed hepatotoxicity at higher concentration, it can work as a mitogen at a lower concentration.en_US
dc.subjectDose-Dependent Paradoxical Effecten_US
dc.subjectMulti-Wall Carbon Nanotubeen_US
dc.subjectHepatocyteen_US
dc.titleDose-Dependent Paradoxical Effect of Multi-Wall Carbon Nanotube on Hepatocyteen_US
dc.typePresentationen_US
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