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http://hdl.handle.net/2080/2768
Title: | Ruthenium-Catalysed Atom-Economic Transformations |
Authors: | Sarkar, Debayan |
Keywords: | Ruthenium Catalysed Atom-Economic Transformations |
Issue Date: | Aug-2017 |
Citation: | RSC Seminar, Kolkata, India, 18 August, 2017. |
Abstract: | At the heart of any chemical synthesis of a natural product or designed small molecule is the need to orchestrate a series of chemical reactions to prepare and functionalize a carbon framework. The advent of transition-metal catalysis has provided chemists with a broad range of new tools to forge C−C and C−X bonds and has resulted in a paradigm shift in synthetic strategy planning. The ruthenium catalysed C−C coupling reaction of propargyl alcohol and Michael acceptor has been demonstrated an enabling methodology for synthesis o α,β-unsaturated ketones as a single geometrical isomers of high yield in an atom-economical fashion. The synthesized α,β-unsaturated ketones are the precursor of poly-substituted piperidones and hexahydroisoquilininones which are the central backbone of many biologically active natural products and pharmaceutical drugs. |
Description: | Copyright of this document is with proceedings publisher. |
URI: | http://hdl.handle.net/2080/2768 |
Appears in Collections: | Conference Papers |
Files in This Item:
File | Description | Size | Format | |
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2017_RSCS_DSarkar_Ruthenium.pdf | Scientific lecturer | 424.83 kB | Adobe PDF | View/Open |
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