Preparation and characterisation of graft Biopolymer to improve sustained Release property

Abstract

In the present piece of research work focuses on grafting Acrylic acid with HPMC to obtain copolymers with improved properties, biodegradable and biocompatible that will be used as hydrogel or water absorbing polymers. To develop a prolong release activity drug delivery system for the medication purpose to enhance drug activity and reduce the frequency of dose via this hydrogel. A novel HPMC-g- acrylic acid hydrogel was prepared by in-situ emulsifier free emulsion polymerization using benzyl peroxide as an initiator through 1-stage grafting. Acrylic Acid could intercalate into layers of HPMC and form graft composites through in situ graft-polymerization with acrylic acid and characterized by XRD, FTIR, Thermal spectra and SEM analysis. Swelling property and biodegradability study of the hydrogel graft polymer were investigated. A study of drug loading and drug release with taking the drug Ciprofloxacin is undertaken with this graft polymer using the dissolution apparatus and UV-visible spectrophotometer.