http://hdl.handle.net/2080/17 2026-04-09T12:44:39Z http://hdl.handle.net/2080/5767 Title: Unit Commitment with Respect to Both Cost and Emission Based on a Day Load Demand in an Integrated Solar and Wind Power System Authors: Sahu, Dibya Ranjan; Mohanty, Sanjeeb; Majhi, Abhilash Asit Kumar Abstract: Emission control has become a critical global challenge due to increasing greenhouse gas (GHG) concentrations, primarily resulting from fossil-fuel-based power generation. In India, the growing electricity demand has intensified dependence on thermal power plants, leading to higher carbon dioxide emissions and associated environmental concerns. This paper addresses the dual objectives of reducing electricity generation cost and minimizing emissions by integrating renewable energy sources with conventional thermal units. Solar photovoltaic (PV) and wind power are incorporated into the generation mix. The problem formulation employs Unit Commitment (UC) to determine the optimal hourly scheduling of generating units and Economic Load Dispatch (ELD) to allocate generation economically among committed units. A 24-hour UC problem for a system of four thermal units is solved using Dynamic Programming. The results demonstrate that coordinating renewable energy with thermal generation significantly decreases operating costs and carbon emissions. The findings highlight the potential of renewable–thermal integration as a viable approach for sustainable and costefficient power system operation. Description: Copyright belong to proceedings publisher. 2026-03-01T00:00:00Z http://hdl.handle.net/2080/5766 Title: Interval Estimation of the Ratio of Scale Parameters for Two Shifted Exponential Populations under Common Location Set-up Authors: Sahoo, Ganesh Kumar; Tripathy, Manas Ranjan Abstract: Under the exponential model, the ratio of the scale parameters corresponds to the hazard ratio, a key measure for comparing reliability across populations. Motivated by this, we study interval estimation for the ratio of scale parameters in two exponential populations with a common location parameter. Several confidence interval methods are developed, including asymptotic-like intervals, MOVER intervals, bootstrap-p and bootstrap-t methods, highest posterior density (HPD) intervals via MCMC, and generalized pivot-based intervals. A simulation study is conducted to evaluate their performance, indicating that the HPD interval performs best in terms of coverage probability and average length. The proposed methods are further illustrated using two real data sets. Description: Copyright belong to proceedings publisher 2026-03-01T00:00:00Z http://hdl.handle.net/2080/5765 Title: Pseudouridine modifications may regulate structure and protein recognition in mitochondrial mRNAs Authors: Dwibedy, Sushree Lipsa Lopamudra; Kumar, Santosh Abstract: Pseudouridine(Ѱ) is one of the most abundant modifications in RNA that plays a crucial role in regulating mRNA function and metabolism. However, the exact mechanism by which Ѱ alters the structure, function and interaction of RBP with the mitochondrial mRNAs is still poorly understood. We investigated mitochondrial mRNAs with Ѱ modification using computational modelling and experimental validation. Predicted secondary structure revealed position-specific thermodynamic contribution. Two of the 4 mRNAs that had Ѱ at the stem position showed maximum destabilisation (0.9 and 1.2kcal/mol), whereas the Ѱ at the loop showed negligible energetic impact. Structural characterisation revealed altered base pair geometry, including twist, shear, torsion, and opening. Removal of pseudouridylation by incellulo knockdown of pseudouridine synthase enzymes resulted in a significant reduction of those mRNA levels in cells. To investigate the functional impact of Ѱ, we obtained a list of RBPs binding those regions from an experimentally validated database and examined whether Ѱ affects the interaction with RBPs. To address this, we performed molecular docking and MDS. We observed that Ѱ showed a differential effect with different RBPs. We found an additional hydrogen bond in the cases of DHX30, MTPAP, and TBRG4. We also observed an alteration in the hydrophobic interaction and the salt bridge. Molecular dynamics simulation confirmed altered complex stability, structural flexibility patterns, and reorganised hydrogen bonding networks in pseudouridine-containing complexes. Overall, this finding suggests that Ѱ modification in mitochondrial respiratory mRNAs might alter structure, thermodynamics and interaction with RBPs and may regulate the respiratory function in mitochondria. Description: Copyright belong to proceeding publisher. 2026-02-01T00:00:00Z http://hdl.handle.net/2080/5764 Title: RNA-RBP Interaction and their Probable Function in the Microdeletion Region 15q11.2 Bp1-Bp2 Authors: Biswal, Smruti Rekha; Kumar, Santosh Abstract: The Burnside-Butler syndrome is a genetic condition which is linked to various disabilities like communication skills, movement disabilities, along with conduct and emotional issues due to microdeletion in BP1-BP2 region of chromosome 15q11.2. There are four protein coding genes CYFIP1, NIPA1, TUBGCP5 and NIPA2 in this region. This research is mainly focused on the interaction between mRNAs and RNA-binding proteins (RBPs) in this region which might give us an insight into the cause of such phenotypes. In this study the RBPs binding with the mRNAs of the genes in this region are revealed by intersection of the eCLIP data downloaded from ENCORE with the genomic positions of the four genes situated in this region. Significant RBPs binding to each gene were filtered by according to the p-values and fold enrichment. Further the binding of top RBP binders FASTKD2 and EFTUD2 with CYFIP1 and TUBGCP5 was validated using WEMSA experiment. The RBPs in this area are mainly found to be involved in regulating the gene expression of the particular genes. This work may help to comprehend the complex connections between mRNA and RBPs in microdeletion region which might further be helpful in developing advanced therapeutics. Description: Copyright belong to course organiser. 2026-03-01T00:00:00Z